Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction
Cis-regulatory elements and trans-acting factors coordinate to regulate T helper cell differentiation. Liu et al. characterize the histone modification and chromatin interaction dynamics in this process. The H3K4me1 landscape established by MLL4 in naive CD4+ T cells is critical for rewiring the chromatin interaction network orchestrated by GATA3 during Th differentiation.