Sun et al. demonstrate that APOE3 Christchurch microglia protect neurons from Aβ-induced Tau pathology by regulating lipid peroxidation and phagocytosis. Targeting APOE and lipid metabolism in microglia represents a promising therapeutic strategy for Alzheimer’s disease.
Obecabtagene autoleucel (obe-cel) is an autologous 41BB-ζ anti-CD19 chimeric antigen receptor (CAR) T-cell therapy which uses an intermediate-affinity CAR to reduce toxic effects and improve…
The American Journal of Human Genetics has published many important findings in human genetics during 75 years of publication. Here we celebrate founding editorial teams,…
Study in professional fighters suggests glial fibrillary acidic protein (GFAP) shows promise as a potential blood biomarker for neurodegenerative disease.
Aims A new molecular subtype classification was proposed for small-cell lung carcinoma (SCLC). We aimed to further validate the classification in various SCLC patient samples…
It isn’t a complete defeat for AMD just yet
The number of mpox cases will continue to rise during the next four weeks before starting to show signs of flattening early next year, the…
A private immigration detention center contractor has sued to block a California law allowing local public health officials to inspect facilities in response to allegations…
A large-scale proteomics study involving 53,026 individuals maps 2,920 plasma proteins to 406 prevalent diseases, 660 incident diseases, and 986 health-related traits, identifying promising biomarkers…
Participating in high-quality peer review makes for better researchers and clinicians. In this commentary, Editorial Fellows from Annals of Internal Medicine provide practical suggestions for…
Kubota says its new KATR farm tractor concept raises the bar in autonomous, zero-emission farming – and they’ve convinced others, too.
