Intraepithelial mast cells drive gasdermin C-mediated type 2 immunity
Intraepithelial mast cells (IEMCs) were first observed 105 years ago, yet their functions remain enigmatic. Yang et al. reveal that IEMCs are required for epithelial gasdermin C activation and IEMC-epithelium crosstalk constitutes a critical step in type 2 immune responses.