Zhang et al. report a randomized phase 2 trial for diffuse large B cell lymphoma (DLBCL) that compared standard of care (R-CHOP) to R-CHOP combined with one of 5 agents matched to an individual lymphoma’s genetics. Overall, the matching strategy significantly outperformed R-CHOP, laying the foundation for a paradigm-shifting phase 3 trial.
(Cell Reports 36, 109673; September 7, 2021)
There is a dearth of genetic and environmental diversity in functional genomics datasets. Research focused on the variant-to-function gap aims to identify molecular QTLs but…
Genetic scores of individuals can be used to predict their traits, such as eventual disease status. However, these scores work best in the ancestry from…
We report on the relationship between leukocyte telomere length (LTL), genetics, and environmental factors in ethnically diverse Africans. LTL is longer in African ancestry individuals…
Systemically administered mRNA aggregates (RNA-LPA) transfect lymphoreticular organs, inducing a massive cytokine/chemokine response that rapidly reprograms the tumor microenvironment while mobilizing dendritic cells/lymphocytes to elicit…
TLR7 is critical for recognizing RNA virus infection and initiating antiviral responses. Bérouti et al. demonstrate how RNase T2 and PLD exonucleases generate RNA fragments for…
The insect gustatory receptors (Grs) are one of the largest families of ion channels in the animal kingdom. Frank et al. unveil the structure of a…
Trends in Plant Science publishes commissioned, peer-reviewed articles featuring basic plant science, from molecular biology through ecology.
(Cell 186, 209–229.e1–e26; January 5, 2023)
Nguyen et al. investigate mechanisms of acquired chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC). By identifying the PRMT1-MAFF/BACH1 axis as a key mechanism of response to…
