Current strategies for HIV-1 cure have not been successful in eliminating the latent reservoir. This Review highlights potential therapeutic strategies that engage the immunology of dendritic cells and natural killer cells in efforts to achieve HIV-1 cure.
Nature Reviews Immunology – Wei et al. report a role for membrane perforation mediated by gasdermin D pores in disruption of the blood–brain barrier.
Nature Reviews Immunology – A preprint by Yi et al. shows a role for the FAS signalling pathway in controlling the persistence of CAR-modified lymphocytes.
Yi et al. (BioRxiv) DOI:10.1101/2024.02.26.582108 In this preprint, Yi et al. investigate the relationship between CAR-T cell persistence and the FAS/FAS-ligand (FAS-L) signaling pathway. The…
Chimeric antigen receptor (CAR)-engineered T and NK cells can cause durable remission of B-cell malignancies; however, limited persistence restrains the full potential of these therapies…
Nature Reviews Immunology – Adrian Liston, professor of pathology at the University of Cambridge, UK, has published several illustrated children’s books on the topic of…
Nature Reviews Immunology – Sex hormones in male mice negatively regulate type 2 innate lymphoid cells in the skin, impairing the induction and activation of…
Nature Reviews Immunology – Genome editing approaches can be used to confer immune-evasive properties to allogeneic cellular immunotherapies, with the aim of achieving persistent responses…
Nature Reviews Immunology – This Review discusses the mechanisms by which common alterations of cancer cell metabolism interfere with immune functions to promote immunoevasion and…
Nature Reviews Immunology – This Review discusses the mechanisms by which common alterations of cancer cell metabolism interfere with immune functions to promote immunoevasion and…
Nature Reviews Immunology – This Review discusses the mechanisms by which common alterations of cancer cell metabolism interfere with immune functions to promote immunoevasion and…
