Durable lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection
Depletion antibodies and genetically engineered mouse models are commonly used to investigate lymphocyte subsets in immunity, albeit with limitations. Kastner et al. develop adeno-associated viral vectors delivering depletion antibodies that eliminate lymphocyte subsets long-term. Leveraging this strategy, they interrogate how B cells and CD8+ T cells control chronic viral infection.
