Focus The coevolution of multiple specialized T follicular regulatory cell subsets has led to fine-tuning of human germinal center responses. Research Articles A five-marker signature identifies scar-associated macrophages that differentiate in response to GM-CSF,…
Human IgG3 with its unique long hinge is a potent activator of intracellular antiviral immunity mediated by TRIM21 and complement.
Targeting PD-1+ cells promotes immune tolerance via peripheral clonal deletion of antigen-specific T cells.
A subset of CD8 T cells with a terminally exhausted epigenetic profile expressed IFN-γ, granzymes, and perforin in bone marrow.
Targeting of GALT by anti-α4β7 therapy is associated with therapeutic responses in ulcerative colitis.
A subset of CD8 T cells with a terminally exhausted epigenetic profile expressed IFN-γ, granzymes, and perforin in bone marrow.
Allogeneic CAR-DNTs with minimal genetic modification show potent anti-tumor activity without off-tumor toxicities.
Spatially resolved profiling of the melanoma microenvironment reveals correlates of response to immune checkpoint inhibitors.
Targeting of GALT by anti-α4β7 therapy is associated with therapeutic responses in ulcerative colitis.
The transcriptional regulator Trim33 controls Flt3L-driven dendritic cell differentiation.
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
