Hyde et al. found elevated HSV-1 protein expression in Alzheimer’s disease, with phosphorylated tau strongly colocalizing with HSV-1 proteins. They demonstrated that tau phosphorylation responds to HSV-1 via the innate immune cGAS-STING pathway, reducing HSV-1 protein expression and increasing neuronal viability, highlighting a role for tau phosphorylation in innate immunity.
Background and ObjectivesPersistent elevation of serum creatine kinase levels (hyperCKemia) as an isolated manifestation presents a diagnostic challenge. Genetic myopathies are frequently involved; however, studies…
1 Department of Surgery, University of Virginia, Charlottesville, VA, United States 2 Department of Surgery, Baylor College of Medicine, Houston, TX, United States 3 Department…
Sports Department of Zhejiang A & F University, Hangzhou, Zhejiang, China Introduction: In recent years, with advancements in wearable devices and biosignal analysis technologies, sports…
1 Faculty of Health Sciences, School of Physical Therapy, University of Weste rn Ontario, London, ON, Canada 2 The Gray Centre for Mobility and Activity,…
Clinical studies have shown that combination therapy of PD-1 and VEGF antibodies significantly improves clinical benefit over PD-1 antibody alone in certain settings. Ivonescimab, an…
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We use sensory feedback to form our perception, and control our movements and forces (actions). There is an ongoing debate about the relation between perception…
A 67-year-old man presented with hemifacial weakness and maculopapular rash, treated as Bell palsy. Initial CT angiogram was normal. 6 weeks later, he developed dizziness,…
Department of Epidemiology and Health Statistics, Scho ol of Public Health, Qingdao University, Qingdao, Shandong, China Introduction: Previous research has suggested a link between the…
New research reveals that certain cells inactivate one parent’s copy of a gene, leading to a bias in gene activity that may explain why some…
