Interferon γ secretion by activated T cells alters the immunopeptidome landscape of cancer cells, enriching for W>F substitutant epitopes. Champagne et al. demonstrate that these induced neoepitopes are widespread, shared between cancer types, and are amenable to adoptive T cell therapy to enhance the efficiency of conventional immunotherapeutic approaches.
Erasure of the starting cell fate is a key process underlying direct neuronal conversion. Cates et al. reveal that microRNAs 9/9∗ and 124 induce a neuronal…
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Metabolic adaptations are key to cancer cell survival in nutrient-limited microenvironments, but strategies for coping with arginine scarcity are poorly understood. Dunlap et al. use CRISPR…
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NEK7 phosphorylation amplifies NLRP3 activation.
ABCC1 mediates the export of cGAMP, but the underlying molecular mechanism of cGAMP recognition and export is not clear. Here, Shinde et al. show that human…
Kunze-Schumacher et al. have developed an experimental and computational framework to generate a quantitative high-resolution map of cell cycle phase durations during murine T cell development. This…
The guidance explains, using a question and answer format, FDA’s current thinking on a number of issues related to the regulation of food allergens, including…
Rössler et al. construct a nonhuman primate (NHP) antigenic map for SARS-CoV-2, showing the antigenic evolution and immune escape of BA.2.86 and descendants. By comparing matching…
Melo Garcia et al. demonstrate that CD38-directed CAR NK cells can overcome acute myeloid leukemia (AML)-induced immune evasion by compensating for CD226 downregulation. They show how…
