A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity
Identifying the optimal diet for patients suffering from autoimmune disease remains challenging. Here, Alexander and colleagues dissect the complex host-microbiome interactions, explaining the protective effects of a ketogenic diet for a mouse model of neuroinflammation. They highlight the importance of host β-hydroxybutyrate and bacterial indole lactate, inspiring more precise interventions.