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Mashup Score: 4Sex steroids and the female brain across the lifespan: insights into risk of depression and Alzheimer's disease - 4 day(s) ago
Despite widespread sex differences in prevalence and presentation of numerous illnesses affecting the human brain, there has been little focus on the effect of endocrine ageing. Most preclinical studies have focused on males only, and clinical studies often analyse data by covarying for sex, ignoring relevant differences between the sexes. This sex- (and gender)-neutral approach is biased and contributes to the absence of targeted treatments and services for all sexes (and genders). Female health has been historically understudied, with grave consequences for their wellbeing and health equity.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 0
With the increase in obesity prevalence worldwide, considerable efforts have been made to investigate the molecular and neurohormonal mechanisms of bodyweight control, as a means to identify novel therapeutic targets. As a paradigmatic example, characterisation of the physiological actions of glucagon-like peptide-1 (GLP-1) paved the way for development of long-acting GLP-1 analogues that are revolutionising the pharmacological management of obesity.1 Similarly, recognition of the fundamental roles of the leptin–melanocortin system in bodyweight homeostasis has opened up potential pathways to manage some forms of obesity.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 24Setmelanotide for the treatment of acquired hypothalamic obesity: a phase 2, open-label, multicentre trial - 4 day(s) ago
These findings support setmelanotide as a novel effective treatment of hypothalamic obesity.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 0Demarcating the benefits of hybrid closed loop therapy in pregnant women with type 1 diabetes - 5 day(s) ago
The role of hybrid closed-loop systems in the clinical management of type 1 diabetes is rapidly expanding. Randomised controlled trials have shown life-changing clinical and quality-of-life benefits beyond those that can be obtained by use of continuous glucose monitoring (CGM) with an insulin pump or multiple daily injection therapy.1 Meta-analyses of trial data confirm substantial glycaemic improvements in people of all ages, with 8–12 percentage points higher time spent in the target glucose range of 3·9–10·0 mmol/L, and lower mean glucose with less or no additional hypoglycaemia.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 16
In pregnant women starting with tighter glycaemic control, AHCL therapy did not improve overall time in target range but improved overnight time in target range, reduced time below range, and improved treatment satisfaction. These data suggest that the MiniMed 780G can be safely used in pregnancy and provides some additional benefits compared with standard insulin therapy; however, it will be important to refine the algorithm to better align with pregnancy requirements.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 5
Melatonin, a hormone primarily produced by the brain’s pineal gland, is typically secreted during darkness, aligning with the time when most people sleep. Melatonin plays a crucial part in signalling the onset of the biological night. It achieves this through multiple mechanisms, including inhibiting wake-promoting orexin neurons located in the hypothalamus, which serves as a central hub for regulating the sleep–wake cycle.1 The fact that melatonin can help to regulate sleep timing might also explain its popularity, particularly in countries where it is available over the counter.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 37
With up to 23 years of follow-up of three large prospective cohorts of middle-aged and older men and women, self-reported melatonin supplement use was not associated with risk of type 2 diabetes or cardiovascular disease. Further research is warranted to assess if melatonin supplement use could mitigate the potential risks of type 2 diabetes and cardiovascular disease associated with rotating night shift work.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 37
Phaeochromocytomas and paragangliomas (PPGLs) release catecholamines leading to catecholamine-induced hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm Hg. CIH crises can be complicated by tachyarrhythmias, hypotension, or life-threatening target organ damage while treatment remains undefined, often requiring co-management between endocrinologists and cardiologists. Furthermore, biochemical diagnosis of a PPGL as a cause of a CIH crisis can be difficult to identify or confounded by comorbid conditions, potentially resulting in misdiagnosis.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 3Reversibility of congenital hypogonadotropic hypogonadism: lessons from a rare disease - 6 day(s) ago
Congenital hypogonadotropic hypogonadism (CHH) is caused by abnormal gonadotropin secretion or action. Although rare, CHH is approximately twice as common in men than in women.1,2 Around 50% of patients with CHH have anosmia (Kallmann syndrome).1,2 CHH is generally first suspected by the absence of puberty at the typical age. Boys and girls of pubertal age with CHH are treated with testosterone or oestrogen to induce secondary sexual characteristics. Men and women with CHH require pulsatile subcutaneous GnRH therapy or subcutaneous injections of luteinising hormone (LH) and follicle-stimulating hormone (FSH) for gametogenesis and fertility.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 19
Applying LCMM to a large cohort of male patients with CHH reversal uncovered two distinct classes of reversal. Genetic investigation combined with careful clinical phenotyping could help surveillance of reversal after withdrawing treatment, representing the first tailored management approach for male patients with this rare endocrine disorder.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
Sex steroids and the #female #brain across the lifespan: insights into risk of #depression and #Alzheimer's disease https://t.co/LXaKVBgtdq #SexSteroids #oestradiol