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Mashup Score: 37
Identifying biomarkers of functional β-cell loss is an important step in the risk stratification of type 1 diabetes. Genetic risk scores (GRS), generated by profiling an array of single nucleotide polymorphisms, are a widely used type 1 diabetes risk-prediction tool. Type 1 diabetes screening studies have relied on a combination of biochemical (autoantibody) and GRS screening methodologies for identifying individuals at high-risk of type 1 diabetes. A limitation of these screening tools is that the presence of autoantibodies marks the initiation of β-cell loss, and is therefore not the best biomarker of progression to early-stage type 1 diabetes.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 1Iodine status in Iran: from deficient to replete - 5 day(s) ago
Thyroid hormones are pivotal regulators of cellular metabolism, growth, and developmental progression. To function effectively, thyroid hormones depend on having an adequate supply of a critical micronutrient called iodine. When the body does not receive enough iodine to produce the necessary thyroid hormones, it can lead to various health issues collectively known as iodine deficiency disorders. These disorders encompass conditions like goitre, congenital hypothyroidism, intellectual impairment, and an increased risk of thyroid cancer.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 12The ongoing quest for worldwide iodine sufficiency - 5 day(s) ago
People in the USA these days rarely think about goitres and iodine deficiency. However, these were very much issues in the country until about a century ago. Drastic improvement began to take place on May 1, 1924, when iodised salt first appeared in US grocery stores. Largely due to this product, severe iodine deficiency is no longer a common problem in the USA. Unfortunately, such deficiency remains a problem in several other countries and is still the world’s foremost cause of preventable intellectual disability.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 4Sex steroids and the female brain across the lifespan: insights into risk of depression and Alzheimer's disease - 6 day(s) ago
Despite widespread sex differences in prevalence and presentation of numerous illnesses affecting the human brain, there has been little focus on the effect of endocrine ageing. Most preclinical studies have focused on males only, and clinical studies often analyse data by covarying for sex, ignoring relevant differences between the sexes. This sex- (and gender)-neutral approach is biased and contributes to the absence of targeted treatments and services for all sexes (and genders). Female health has been historically understudied, with grave consequences for their wellbeing and health equity.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 0Measuring serum testosterone in women - 6 day(s) ago
When requesting a blood testosterone test in women it is key to be aware of the limitations of the commercial immunoassays used by most pathology laboratories. Major limitations of reported low blood testosterone concentrations in women must be recognised before deciding whether the result is a valid, reproducible, and clinically meaningful measurement. Physiologically, blood testosterone in women derives from two sources—direct secretion by ovaries with possibly some adrenal contribution, and from pro-androgen precursors (predominantly from the adrenals in postmenopausal women) that are subsequently converted to testosterone peripherally.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 1SGLT2 inhibitors in clinical practice - 6 day(s) ago
On Sept 15, 2015, in Stockholm, the attendees at the Congress of the European Association for the Study of Diabetes were stunned by the presentation of the first randomised investigation of a sodium–glucose co-transporter-2 (SGLT2) inhibitor, empagliflozin, in the EMPA-REG OUTCOME trial1 in patients with type 2 diabetes and atherosclerotic cardiovascular disease. The unexpected results (ie, an early-onset reduction in morbidity and mortality) caused the audience to stand up and applaud the first evidence that a drug, developed to lower glucose concentration, was associated with cardiovascular superiority due to a reduction of heart failure.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 37
SGLT2 inhibitors reduced heart failure events and cardiovascular death in patients with heart failure, type 2 diabetes, chronic kidney disease, and atherosclerotic cardiovascular disease. These effects were consistent across a wide range of subgroups within these populations. This supports the eligibility of a large population with cardiorenal-metabolic diseases for treatment with SGLT2 inhibitors.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 100Sleep: a neglected public health issue - 7 day(s) ago
Controlled by circadian rhythms and sleep–wake homeostasis, sleep is a state of reduced mental and physical activity—a time for body and mind to recharge in preparation for the next day. Although adults aged 18 years and older are recommended to get 7–9 h of sleep per day (and children up to 12 h), the 24/7 economy, modern lifestyles, job stresses, and living environments adversely affect the timing, duration, and quality of sleep for many people.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 37
Identifying biomarkers of functional β-cell loss is an important step in the risk stratification of type 1 diabetes. Genetic risk scores (GRS), generated by profiling an array of single nucleotide polymorphisms, are a widely used type 1 diabetes risk-prediction tool. Type 1 diabetes screening studies have relied on a combination of biochemical (autoantibody) and GRS screening methodologies for identifying individuals at high-risk of type 1 diabetes. A limitation of these screening tools is that the presence of autoantibodies marks the initiation of β-cell loss, and is therefore not the best biomarker of progression to early-stage type 1 diabetes.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 210Acromegaly: pathogenesis, diagnosis, and management - 8 day(s) ago
Growth hormone-secreting pituitary adenomas that cause acromegaly arise as monoclonal expansions of differentiated somatotroph cells and are usually sporadic. They are almost invariably benign, yet they can be locally invasive and show progressive growth despite treatment. Persistent excess of both growth hormone and its target hormone insulin-like growth factor 1 (IGF-1) results in a wide array of cardiovascular, respiratory, metabolic, musculoskeletal, neurological, and neoplastic comorbidities that might not be reversible with disease control.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
New—Prediction of progression to type 1 #diabetes with dynamic #biomarkers and #risk scores https://t.co/jvDEewaeGC #T1D