• Mashup Score: 1

    BACKGROUND: Real-world low-risk transcatheter aortic valve replacement (TAVR) outcomes in the United States have not been assessed comprehensively versus pivotal trials, which is a key component of measuring the quality of clinical technology adoption. METHODS: We identified heart team–designated low-risk patients undergoing TAVR for trileaflet severe, symptomatic aortic stenosis in the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Registry, as well as a subset of patients who met low-risk trial inclusion and exclusion criteria, from January 2020 to March 2024. Outcomes (mortality, stroke, new pacemaker, and “alive and well,” defined as alive at 1 year with Kansas City Cardiomyopathy Questionnaire score ≥60 and ≤10-point decrease from baseline) at 30 days and 1 year were assessed. Multivariable models were developed to assess predictors of death within 1 year after TAVR. RESULTS: Among 383 030 patients who underwent TAVR during the study period, 108 40

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    • Real life is not always the same than RCT. Outcomes of Transcatheter Aortic Valve Replacement in Low-Risk Patients in the United States: A Report From the STS/ACC TVT Registry | Circulation https://t.co/SiKSRaPuJZ

  • Mashup Score: 4

    BACKGROUND: The anatomic and physiological changes associated with severe aortic stenosis may influence the functional evaluation of coronary stenoses. In this study, we aimed to assess changes in functional resting and hyperemic indices before and immediately after transcatheter aortic valve implantation (TAVI) and their relationship with microvascular resistance. METHODS: In this pooled analysis of 3 prospective observational studies, fractional flow reserve (FFR), resting full-cycle ratio (RFR), and resting Pd/Pa were measured in patients with severe aortic stenosis before and after TAVI in the left anterior descending artery. Coronary microcirculation was also assessed using thermodilution-based methods, with microvascular resistance reserve (cutoff ≤3) used to identify coronary microvascular dysfunction. RESULTS: A total of 126 patients were included. Baseline Pd/Pa, RFR, and FFR measurements were 0.93±0.04, 0.90±0.07, and 0.89±0.07, respectively. Immediately post-TAVI, a small bu

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    • Coronary Functional evaluation pre & post #TAVI #FFR #RFR https://t.co/QmfTCtIRSa https://t.co/ZvzQjs29ls