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Mashup Score: 7NanoString Technologies to Be Acquired by Bruker Corporation - 25 day(s) ago
Bruker Wins Competitive Auction Acquisition Ensures Continued Customer Access to NanoString’s Products Transaction Expected to Close in early-May 2024 NanoString Technologies, Inc. (“NanoString” or “the Company”), a leading provider of life science tools for discovery and translational research, today announced that substantially all of its assets will be acquired by Bruker Corporation (“Bruker”), a global life science analytical instrument company, for approximately $392.6 million in cash consi
Source: investors.nanostring.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 24
Establishing a comprehensive map of trans-gene regulatory effects is a critical step toward understanding complex trait and disease genetics. However, detecting these effects is extremely difficult due to statistical and computational challenges. Wang et al. developed a powerful tool, trans-PCO, to detect high-quality trans-genetic effects on gene networks, which opens up new opportunities to learn the impact of trait-associated loci on gene regulatory networks.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 24
Establishing a comprehensive map of trans-gene regulatory effects is a critical step toward understanding complex trait and disease genetics. However, detecting these effects is extremely difficult due to statistical and computational challenges. Wang et al. developed a powerful tool, trans-PCO, to detect high-quality trans-genetic effects on gene networks, which opens up new opportunities to learn the impact of trait-associated loci on gene regulatory networks.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 216Cell-type-specific and disease-associated expression quantitative trait loci in the human lung - 2 month(s) ago
Nature Genetics – Single-cell transcriptomics and expression quantitative trait locus mapping in 114 lung tissue samples, including 66 with interstitial lung disease, highlight the…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 10Genetic regulatory effects in response to a high-cholesterol, high-fat diet in baboons - 2 month(s) ago
Lin et al. characterized transcriptional and gene regulatory responses to high dietary fat and cholesterol in three metabolically active tissues in a longitudinal study of baboons. They highlight the intricate and dynamic interplay between diet, genetic variants, and gene expression. The results illustrate the potential of GxE eQTL studies in non-human primates to advance the understanding of the role of non-coding variants in human complex disease.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 39Type 2 airway inflammation in chronic obstructive pulmonary disease - 2 month(s) ago
Chronic Obstructive Pulmonary Disease (COPD) is a significant global health burden due to its rising prevalence and the complexity of its management [1]. The development of personalized medicine approaches tailored to individual patient needs and disease characteristics is seen as a promising direction, but it faces challenges in implementation and accessibility [2]. One of the main limitations in the treatment of COPD patients is the heterogeneous nature of its pathogenesis, as it involves the activation of multiple inflammatory cells, such as lymphocytes, neutrophils, macrophages, and eosinophils, which contribute to the inflammatory response [3]. Of all the culprits involved in COPD pathogenesis, type 2 inflammation represents a distinct pathway, primarily involving type 2 helper T cells (Th2 cells) and associated cytokines [3]. The emergence of type 2 monoclonal antibodies such as anti-IL5, anti-IL33, anti-TSLP and anti-IL4R, initially developed for the treatment of severe uncontro
Source: erj.ersjournals.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 35Type 2 airway inflammation in chronic obstructive pulmonary disease - 2 month(s) ago
Chronic Obstructive Pulmonary Disease (COPD) is a significant global health burden due to its rising prevalence and the complexity of its management [1]. The development of personalized medicine approaches tailored to individual patient needs and disease characteristics is seen as a promising direction, but it faces challenges in implementation and accessibility [2]. One of the main limitations in the treatment of COPD patients is the heterogeneous nature of its pathogenesis, as it involves the activation of multiple inflammatory cells, such as lymphocytes, neutrophils, macrophages, and eosinophils, which contribute to the inflammatory response [3]. Of all the culprits involved in COPD pathogenesis, type 2 inflammation represents a distinct pathway, primarily involving type 2 helper T cells (Th2 cells) and associated cytokines [3]. The emergence of type 2 monoclonal antibodies such as anti-IL5, anti-IL33, anti-TSLP and anti-IL4R, initially developed for the treatment of severe uncontro
Source: erj.ersjournals.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 29Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial - 2 month(s) ago
Nature Medicine – In a large trial of patients with recurrent high-grade gliomas, IL-13Rα2-targeting CAR-T cells were feasible to manufacture and well tolerated when delivered via intratumoral…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 29Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial - 2 month(s) ago
Nature Medicine – In a large trial of patients with recurrent high-grade gliomas, IL-13Rα2-targeting CAR-T cells were feasible to manufacture and well tolerated when delivered via intratumoral…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 29Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial - 2 month(s) ago
Nature Medicine – In a large trial of patients with recurrent high-grade gliomas, IL-13Rα2-targeting CAR-T cells were feasible to manufacture and well tolerated when delivered via intratumoral…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
RT @julemieux1: .@nanostringtech will be acquired by @bruker #spatial https://t.co/eCx0J1RvUI