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Mashup Score: 2Monocyte-derived cells but not Microglia cause Oxidative Tissue Damage in Neuroinflammation - 3 month(s) ago
Multiple sclerosis (MS) is characterized by neuroinflammation, oxidative stress, iron toxicity and mitochondrial dysfunction. Reactive oxygen species (ROS) produced by mononuclear phagocytes (MPs) are widely held to drive tissue damage, yet the specific roles of central nervous system (CNS)- resident versus CNS-invading MPs remain unclear. Here, by combining single-cell profiling with conditional gene targeting, we systematically dissected and interfered with ROS production across CNS MPs in a preclinical model for neuroinflammation. We show that CNS-invading monocyte derived cells (MdCs) exhibit a higher oxidative stress gene signature and produce more ROS compared to CNS-resident microglia. While NADPH oxidase 2 (NOX2), a phagocytic source of ROS, proved redundant, our findings underscore the critical role of mitochondrial ROS (mtROS) in driving oxidative tissue damage. Quenching mtROS through mitocatalase overexpression in MdCs, but not microglia, significantly alleviated neuroinfla
Source: www.biorxiv.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 02024-oct-hor - 3 month(s) ago
In the face of tumour and viral challenge, stem-like TCF-1+PD-1+ cells (TSL) represent a critical CD8+ subset capable of self-renewal and replenishing intratumoural cytotoxic effector T cells. Crucially, TSL are reported to expand upon immune checkpoint blockade, thus potentiating therapeutic recovery of anti-tumour T cell responses. In a recent pre-print, Hor et al. deeply interrogate stem-like T cell niches in tumour-draining lymph nodes (tDLNs), defining a SLAMF6+TSL subset with high TCR affinity.
Source: www.preprintclub.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Further discussion from @preprintclub here: https://t.co/8yUqjSXJLr
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Mashup Score: 6Conferences | Keystone Symposia - 4 month(s) ago
February 2-5, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada Scientific Organizers: Shruti Naik, Keke C. Fairfax and Renato Ostuni February 2-5, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada Scientific Organizers: Shruti Naik, Keke C. Fairfax and Renato Ostuni Important Deadlines Early Registration Deadline: Dec. 12, 2024 Scholarship Deadline: Nov. 5, 2024 Short Talk Abstract Deadline: Nov. 5, 2024 Poster Abstract Deadline: Jan. 9, 2025 Inflammatory memory is remnant of anti-pathogen
Source: www.keystonesymposia.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
Lucy Bird from NRI will be attending the joint Keystone symposia on T cells and innate immune memory in Feb in Vancouver. Details here: https://t.co/iP7w5cY9iK #KSTCells25 #KSInnateImmune25 https://t.co/Oor1jUGBLI
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Mashup Score: 7An inhibitory PRR reels in the neutrophil response to NETs - 5 month(s) ago
Nature Reviews Immunology – MICL regulates neutrophil responses by serving as an inhibitory pattern-recognition receptor for NETs.
Source: www.nature.comCategories: General Medicine News, Allergy-ImmunologyTweet-
An inhibitory PRR reels in the neutrophil response to NETs https://t.co/OmnO5SBGEw https://t.co/aU5JOnmupY
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Mashup Score: 1
Nature Reviews Immunology – Publisher Correction: Role of thymic stromal lymphopoietin in allergy and beyond
Source: www.nature.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Publisher Correction: Role of thymic stromal lymphopoietin in allergy and beyond https://t.co/INm0NuXmNR
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Mashup Score: 229Understanding vertebrate immunity through comparative immunology - 5 month(s) ago
Nature Reviews Immunology – Technological advances in cellular and molecular immunology are providing unprecedented new insights into evolutionary immunology. This Perspective highlights new…
Source: www.nature.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Understanding vertebrate immunity through comparative immunology https://t.co/oV5wy5ux0W https://t.co/KAQeqdvkIm
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Mashup Score: 10Mitochondrial tonic for adoptive T cell therapies - 5 month(s) ago
Nature Reviews Immunology – A study in Cell describes a platform to supply exogenous mitochondria to CD8+ T cells via nanotubes, which boosts their antitumour efficacy.
Source: www.nature.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Mitochondrial tonic for adoptive T cell therapies https://t.co/mgpuasPGeE https://t.co/grlAsPgqjg
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Mashup Score: 242Antigen presentation for central tolerance induction - 5 month(s) ago
Nature Reviews Immunology – For effective central T cell tolerance, developing thymocytes must encounter a diverse range of self-antigens presented by various thymic cells. Here, the authors…
Source: www.nature.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Antigen presentation for central tolerance induction https://t.co/BJ6bBH75Tc https://t.co/2OHpDQdhaC
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Mashup Score: 211Inducible antibacterial responses in macrophages - 5 month(s) ago
Nature Reviews Immunology – Macrophages are innate immune sentinels providing frontline defence against infection. This Review describes the inducible mechanisms used by macrophages to kill…
Source: www.nature.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Inducible antibacterial responses in macrophages https://t.co/Y4dTcTjFYj https://t.co/NiJpbcL6aY
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Mashup Score: 242Antigen presentation for central tolerance induction - 5 month(s) ago
Nature Reviews Immunology – For effective central T cell tolerance, developing thymocytes must encounter a diverse range of self-antigens presented by various thymic cells. Here, the authors…
Source: www.nature.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Antigen presentation for central tolerance induction https://t.co/BJ6bBH75Tc https://t.co/2OHpDQdhaC
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Original preprint here: https://t.co/U8w3igNTQg