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Mashup Score: 22The BAP1 nuclear deubiquitinase is involved in the nonhomologous end-joining pathway of double-strand DNA repair through interaction with DNA-PK - 11 month(s) ago
BRCA1-associated protein 1 (BAP1) has emerged as a major tumor suppressor gene in diverse cancer types, notably in malignant pleural mesothelioma (DPM), and has also been identified as a germline cancer predisposition gene for DPM and other select cancers. However, its role in the response to DNA damage has remained unclear. Here, we show that BAP1 inactivation is associated with increased DNA…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3
This study suggests that cells need to inactivate mTOR to survive nutrient stress, which could explain the rarity of mTOR mutations and the limited clinical activity of mTOR inhibitors in cancer.
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet-
Activating mTOR Mutations Are Detrimental in Nutrient-Poor Conditions | Cancer Research | American Association for Cancer Research https://t.co/3U398t64kE
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Mashup Score: 1MSK Research Highlights September 29, 2023 - 1 year(s) ago
New research from MSK develops a method for analyzing cancer cells that survive treatment for acute myeloid leukemia; identifies a transcription factor that orchestrates natural killer cell response; and finds vepafestinib is a promising therapeutic for the treatment of RET-driven cancers.
Source: www.mskcc.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
MSK Research Highlights September 29, 2023 https://t.co/vBms0qytCL
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Mashup Score: 0Please wait whilst we redirect you - 2 year(s) ago
About ScienceDirectRemote accessShopping cartAdvertiseContact and supportTerms and conditionsPrivacy policyWe use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies.Copyright © 2023 Elsevier B.V. or its licensors or contributors. ScienceDirect® is a registered trademark of Elsevier B.V.ScienceDirect® is a registered trademark…
Source: www.sciencedirect.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Time to move beyond the serial "whack-a-mole" paradigm of monotherapy for single genetic alterations that activate MAPK signaling? With CGP & advances in drug dev, we can hit multiple independent oncogenic pathways simultaneously. https://t.co/qUpgvSXFqC https://t.co/RMMYpVINd8
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Mashup Score: 3
A non-covalent inhibitor that binds preferentially to the inactive state of KRAS while sparing NRAS and HRAS is reported, indicating that most KRAS oncoproteins cycle between an active state and an inactive state in cancer cells.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @BarbMarte: new out in Nature https://t.co/aaNXp1sMVB
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Mashup Score: 11How thought itself can drive tumour growth - 2 year(s) ago
How tumour–neuron interactions affect cognition and survival times.
Source: www.nature.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @BarbMarte: and the News & Views https://t.co/eZWujJkSZk
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Mashup Score: 12Lung adenocarcinoma promotion by air pollutants - Nature - 2 year(s) ago
Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @BarbMarte: new out in Nature https://t.co/s0EeHYm6z9
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Mashup Score: 1
Evaluation of suspected myeloid neoplasms involves testing for recurrent, diagnostically and therapeutically relevant genetic alterations. Current molecular testing requires multiple technologies, different domains of expertise, and unconnected workflows, resulting in variable, lengthy turnaround times that can delay treatment. To address this unmet clinical need, we evaluated the Oncomine…
Categories: Hem/Oncs, Latest HeadlinesTweet-
One of the most challenging and critical areas in molecular diagnostics: Rapid Detection of Somatic DNA and RNA Aberrations in Myeloid Neoplasms https://t.co/lUYil53ld8
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Mashup Score: 0Expanded genetic testing of GIST patients identifies high proportion of non-syndromic patients with germline alterations - PubMed - 2 year(s) ago
Traditional genetic testing for patients with gastrointestinal stromal tumors (GISTs) focus on those with syndromic features. To assess whether expanded genetic testing of GIST patients could identify hereditary cancer predisposition, we analyzed matched tumor-germline sequencing results from 103 pa …
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
Expanded genetic testing of GIST patients identifies high proportion of non-syndromic patients with germline altera… https://t.co/DRVTLuCNyK
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Mashup Score: 1Defining Novel DNA Virus-Tumor Associations and Genomic Correlates Using Prospective Clinical Tumor/Normal Matched Sequencing Data - PubMed - 2 year(s) ago
This study is the largest analysis of DNA viruses in solid tumors with associated genomics. To achieve this, a novel method for discovery of DNA viruses from matched tumor/normal next-generation sequencing samples was developed and validated. This method performed comparably to reference methods for …
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
@Aiims1742 @obenaufa @CD_AACR @JMGardnerMD @ASDPTweets Nice to see our 2022 findings linking HPV42 to DPA confirmed! Same approach, same dataset? https://t.co/t6B0wSkMNw @MSKPathology #MSKimpact
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Our latest contribution to the role of BAP1 in mesothelioma: another possible mechanism of the effect of BAP1 inactivation on DNA repair. https://t.co/QIXLKqEFwZ