-
Mashup Score: 103FDA approves acalabrutinib with bendamustine and rituximab - 2 month(s) ago
On January 16, 2025, the FDA granted traditional approval to acalabrutinib (Calquence, AstraZeneca) with bendamustine and rituximab for adults with previously untreated mantle cell lymphoma (MCL) who are ineligible for autologous hematopoietic stem cell transplantation (HSCT).
Source: www.fda.govCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 5Drug tolerant persister cell plasticity in cancer: A revolutionary strategy for more effective anticancer therapies - PubMed - 5 month(s) ago
Non-genetic mechanisms have recently emerged as important drivers of anticancer drug resistance. Among these, the drug tolerant persister (DTP) cell phenotype is attracting more and more attention and giving a predominant non-genetic role in cancer therapy resistance. The DTP phenotype is characteri …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
In Sig Trans Target Ther, a Hangzhou team comprehensively reviews DTPs and feasibility of small molecules, natural products, and drug repurposing to simultaneously inhibit and eliminate DTPs, providing long-term therapeutic results. https://t.co/o0Qsj1l99e https://t.co/wX5WyrU9RB
-
-
Mashup Score: 8Cancer drug-tolerant persister cells: from biological questions to clinical opportunities - PubMed - 6 month(s) ago
The emergence of drug resistance is the most substantial challenge to the effectiveness of anticancer therapies. Orthogonal approaches have revealed that a subset of cells, known as drug-tolerant ‘persister’ (DTP) cells, have a prominent role in drug resistance. Although long recognized in bacterial …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
DTPs are the ultimate shapeshifters: cell reprogramming, phenotypic adaptations, TME modulation, and genetic adaptation. In Nat Rev Cancer, an international team led by U of Torino’s Bardelli share a Roadmap to understand this dangerous cell type. https://t.co/nEmE3MlARl https://t.co/gyWfJrWqE0
-
-
Mashup Score: 7
Dynamic alterations in cellular phenotypes during cancer progression are attributed to a phenomenon known as ‘lineage plasticity’. This process is associated with therapeutic resistance and involves concurrent shifts in metabolic states that facilitate adaptation to various stressors inherent in malignant growth. Certain metabolites also serve as synthetic reservoirs for chromatin modification, thus linking metabolic states with epigenetic regulation. There remains a critical need to understand the mechanisms that converge on lineage plasticity and metabolic reprogramming to prevent the emergence of lethal disease. This review attempts to offer an overview of our current understanding of the interplay between metabolic reprogramming and lineage plasticity in the context of cancer, highlighting the intersecting drivers of cancer hallmarks, with an emphasis on solid tumors.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet-
Phenotype/lineage plasticity of cancer cells is associated with therapy resistance. In Trends in Cancer, Perez et al. of Cedars-Sinai review the relationships of metabolic reprogramming and epigenetics to such plasticity. https://t.co/Q86d3AJSBp https://t.co/JgRIiepUXq
-
-
Mashup Score: 24Decoding and overcoming T cell exhaustion: Epigenetic and transcriptional dynamics in CAR-T cells against solid tumors - PubMed - 7 month(s) ago
T cell exhaustion, which is observed in various chronic infections and malignancies, is characterized by elevated expression of multiple inhibitory receptors, impaired effector functions, decreased proliferation, and reduced cytokine production. Notably, while adoptive T cell therapies, such as chim …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
In Molecular Therapy, Seoul National University’s Ahn et al. review properties of T-cell exhaustion and revitalization strategies to improve therapeutic impact. Approaches to improve long-term persistence of CAR-T and T cells are especially compelling. https://t.co/UhxbWtdvHV https://t.co/xOnxFxJP9I
-
-
Mashup Score: 8
Before molecular pathways in cancer were known to a depth that could predict targets, drug development relied on phenotypic screening, where the effectiveness of candidate chemicals is judged from functional readouts without considering the mechanisms of action. The unraveling of tumor-specific path …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
Innovating Cancer Drug Discover with Refined Phenotypic Screens makes it clear that phenotype- AND target-driven discovery are necessary for finding cures, and that technological advances have improved #phenotypic screens’ #discovery power. https://t.co/CoZCQuuK4T https://t.co/HYJzX0xH65
-
-
Mashup Score: 18Mechanisms of lymphoma-stromal interactions focusing on tumor-associated macrophages, fibroblastic reticular cells, and follicular dendritic cells - 7 month(s) ago
The interaction between cancer cells and stromal cells contributes to the pathogenesis of various types of tumors in the tumor microenvironment (TME). …
Source: www.jstage.jst.go.jpCategories: General Medicine News, Hem/OncsTweet-
In #MCL and other lymphomas, interactions between tumor cells and stromal cells are critically important. In J Clin Exp Hematop, Ohe of Yamagata Univ summarizes these interactions for 4 lymphomas, and describes spatial analysis to analyze them. https://t.co/RlV5GcThfB https://t.co/j9duaq3lCd
-
-
Mashup Score: 18MGA deletion leads to Richter's transformation by modulating mitochondrial OXPHOS - PubMed - 7 month(s) ago
Richter’s transformation (RT) is a progression of chronic lymphocytic leukemia (CLL) to aggressive lymphoma. MGA (Max gene associated), a functional MYC suppressor, is mutated at 3% in CLL and 36% in RT. However, genetic models and molecular mechanisms of MGA deletion that drive …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
A City of Hope group developed a Richter’s transformation (RT) model by disrupting Mga in a CLL model. In Sci Transl Med, they show the Mga-Nme1 axis drives the CLL-RT transition through OXPHOS, suggesting new therapeutic possibilities for RT patients. https://t.co/KCC0y0oeTy https://t.co/lH9JqDNBmG
-
-
Mashup Score: 12Generation of non-genetically modified, CAR-like, NK cells - 7 month(s) ago
Background Natural killer (NK) cell therapy is considered an attractive and safe strategy for anticancer therapy. Nevertheless, when autologous or allogenic NK cells are used alone, the clinical benefit has been disappointing. This is partially due to the lack of target specificity. Recently, CD19-specific chimeric antigen receptor (CAR)-NK cells have proven to be safe and potent in patients with B-cell tumors. However, the generation of CAR-NK cells is a complicated manufacturing process. We aim at developing a targeted NK cell therapy without the need for cellular genetic modifications. We took advantage of the natural expression of the IgG Fc receptor CD16a (FcγRIIIa) to induce strong antigen-specific effector functions through antibody-dependent cell-mediated cytotoxicity (ADCC). We have generated the new technology “Pin”, which enables the arming of modified monoclonal antibodies (mAbs) onto the CD16a of ex vivo expanded NK (eNK) cells. Methods Ex vivo eNK were prepared from umbil
Source: jitc.bmj.comCategories: General Medicine News, Hem/OncsTweet-
Coënon et al. (Univ. Montpellier) show that when monoclonal antibodies targeting tumor antigens undergo Fc-region Pin mutations, they bind avidly to NK cells, making them CAR-like NK cells that lyse tumor cell via ADCC; effective in #MCL and #DLBCL. https://t.co/rw8TunwQ0T https://t.co/RcgLLcHVdj
-
-
Mashup Score: 7Highly parallel production of designer organoids by mosaic patterning of progenitors - PubMed - 8 month(s) ago
Organoids derived from human stem cells are a promising approach for disease modeling, regenerative medicine, and fundamental research. However, organoid variability and limited control over morphological outcomes remain as challenges. One open question is the extent to which engineering control ove …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
Fascinating Cell article showing construction of kidney #organoids using 2D #micropatterning of two types of kidney cells followed by ssDNA tether cleaving and 3D culture. An inspiration and primer for researchers interested in designer organoids. https://t.co/R85Nh3Yf64 https://t.co/RqpQqqPdqw
-
FDA approves acalabrutinib with bendamustine and rituximab for previously untreated mantle cell lymphoma | FDA https://t.co/R2CvLQPian