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Mashup Score: 25Use of over-the-counter supplements, sleep aids and analgesic medicines in rheumatology: results of a cross-sectional survey - 10 day(s) ago
AbstractObjectives. Pain, fatigue and sleep disturbances are common symptoms in patients with rheumatic and musculoskeletal diseases (RMDs) that may prompt
Source: academic.oup.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 25
Although opioids continue to be used internationally for noncancer pain, evidence to date on the com
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
New paper ✨ As part of an international collaboration between UK, Canada & US we evaluated the risk of death between different prescribed opioids in people with non-cancer pain (Spoiler: Type of opioid & daily dose matter💊) https://t.co/fgQYHUsOif w/ @WGDixon @DBatesSafety
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Mashup Score: 18
Clinical question In adult patients with inflammatory bowel disease, inflammatory arthritis (rheumatoid arthritis, spondyloarthritis, psoriatic arthritis), or psoriasis taking biologic drugs, does proactive therapeutic drug monitoring (TDM) improve outcomes as compared with standard care? Context and current practice Standard care for immune mediated inflammatory diseases includes prescribing biologic drugs at pre-determined doses. Dosing may be adjusted reactively, for example with increased disease activity. In proactive TDM, serum drug levels and anti-drug antibodies are measured irrespective of disease activity, and the drug dosing is adjusted to achieve target serum drug levels, usually within pre-specified therapeutic ranges. The role of proactive TDM in clinical practice remains unclear, with conflicting guideline recommendations and emerging evidence from randomised controlled trials. The evidence Linked systematic review and pairwise meta-analysis which identified 10 trials in
Source: www.bmj.comCategories: General Medicine News, RheumatologyTweet-
Pleasure to be part of this recommendations group led by @leticiakawano & @EKristianslund Great to see this published in @bmj_latest https://t.co/oAJHUeAsHB https://t.co/5sjNLOZUSm
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Mashup Score: 23Clinical indications associated with new opioid use for... : PAIN - 1 month(s) ago
tions associated with new opioid initiation in noncancer pain using nationally representative UK data. Primary care electronic health records from January 1, 2006, to September 31, 2021, were used from the Clinical Research Practice Datalink to identify incident opioid prescriptions. Patient histories were reviewed using code lists for opioid-related conditions with a 5-year look-back for chronic conditions and a 1-year look-back for surgical indications before opioid initiation. In total, 3,030,077 new opioid use episodes in 2,027,402 patients were identified, with 61% being women, 77% aged 45 years and older, and 48% from the highest deprivation quintile. Ten systems associated with opioid initiation were identified, which were not mutually exclusive, as patients could have opioids prescribed for multiple indications. The most common were musculoskeletal (80.8%), respiratory (57.6%), infections (30.4%), trauma/injury (20.4%), neurology (19.9%), and postsurgical indications (5.5%). Os
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
New paper💫 We evaluated clinical indications associated with new opioid prescriptions for non-cancer pain in the UK across >2M people MSK conditions were most common & overlapped with other clinical systems 🫁🩻🧠 led by @carlosraul_ram & @MaxLyon1 https://t.co/lWEqJsIjTq https://t.co/2edQztbxIk
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Mashup Score: 4
Professor/Reader/Senior Lecturer and Honorary Consultant in Rheumatology
Source: jobs.ncl.ac.ukCategories: General Medicine News, RheumatologyTweet-
RT @ProfJohnIsaacs: We are recruiting! Come and join a fab team at our #EULAR Centre of Excellence: https://t.co/UiVF22Utba @NHIPartners @E…
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Mashup Score: 30Factors associated with long-term opioid use among patients with axial spondyloarthritis or psoriatic arthritis who initiated opioids - 3 month(s) ago
AbstractObjective. Up to one in five patients with axial spondyloarthritis (AxSpA) or psoriatic arthritis (PsA) newly initiated on opioids transition to lo
Source: academic.oup.comCategories: General Medicine News, RheumatologyTweet-
Our work on factors associated w/ long term opioids in AxSpa & psoriatic arthritis patients who were new starters out in @RheumJnl Using UK primary care EHRs, some included 🚬 Current smoking 📶 Social deprivation 🫁🫀comorbidities ++ 😣 fibromyalgia https://t.co/zJkTGSrdeX
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Mashup Score: 20
Background Opioids administered in hospital during the immediate postoperative period are likely to influence post-surgical outcomes, but inpatient prescribing during the admission is challenging to access. Modified-release(MR) preparations have been especially associated with harm, whilst certain populations such as the elderly or those with renal impairment may be vulnerable to complications. This study aimed to assess postoperative opioid utilisation patterns during hospital stay for people admitted for major/orthopaedic surgery. Methods Patients admitted to a teaching hospital in the North-West of England between 2010–2021 for major/orthopaedic surgery with an admission for ≥1 day were included. We examined opioid administrations in the first seven days post-surgery in hospital, and “first 48 hours” were defined as the initial period. Proportions of MR opioids, initial immediate-release(IR) oxycodone and initial morphine milligram equivalents (MME)/day were calculated and summarise
Source: journals.plos.orgCategories: General Medicine News, RheumatologyTweet-
New paper ✨: We obtained hospital electronic health records from >50k patients post orthopaedic & major surgery to assess inpatient opioid use, to describe current practices & determine future opportunities for safer prescribing https://t.co/BgIkWUk4kd
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Mashup Score: 15Machine learning identifies risk factors associated with long-term opioid use in fibromyalgia patients newly initiated on an opioid - 6 month(s) ago
Objectives Fibromyalgia is frequently treated with opioids due to limited therapeutic options. Long-term opioid use is associated with several adverse outcomes. Identifying factors associated with long-term opioid use is the first step in developing targeted interventions. The aim of this study was to evaluate risk factors in fibromyalgia patients newly initiated on opioids using machine learning. Methods A retrospective cohort study was conducted using a nationally representative primary care dataset from the UK, from the Clinical Research Practice Datalink. Fibromyalgia patients without prior cancer who were new opioid users were included. Logistic regression, a random forest model and Boruta feature selection were used to identify risk factors related to long-term opioid use. Adjusted ORs (aORs) and feature importance scores were calculated to gauge the strength of these associations. Results In this study, 28 552 fibromyalgia patients initiating opioids were identified of which 736
Source: rmdopen.bmj.comCategories: General Medicine News, RheumatologyTweet-
Pleased to share our new paper ✨ We used #machinelearning to identify risk factors of long-term opioid use in patients with fibromyalgia using national primary care data. Could help tailor better access to pain management support & closer monitoring 🔍 https://t.co/7aExNbvMTB
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Mashup Score: 21Development and evaluation of a text analytics algorithm for automated application of national COVID-19 shielding criteria in rheumatology patients - 8 month(s) ago
Introduction At the beginning of the COVID-19 pandemic, the UK’s Scientific Committee issued extreme social distancing measures, termed ‘shielding’, aimed at a subpopulation deemed extremely clinically vulnerable to infection. National guidance for risk stratification was based on patients’ age, comorbidities and immunosuppressive therapies, including biologics that are not captured in primary care records. This process required considerable clinician time to manually review outpatient letters. Our aim was to develop and evaluate an automated shielding algorithm by text-mining outpatient letter diagnoses and medications, reducing the need for future manual review. Methods Rheumatology outpatient letters from a large UK foundation trust were retrieved. Free-text diagnoses were processed using Intelligent Medical Objects software (Concept Tagger), which used interface terminology for each condition mapped to Systematized Medical Nomenclature for Medicine–Clinical Terminology (SNOMED-CT)
Source: ard.bmj.comCategories: General Medicine News, RheumatologyTweet-
📣New paper today in @ARD_BMJ Development of a text analytics algorithm for automated application of national #COVID shielding criteria Example of how an #NLP based- algorithm can complement practice & could improve transparency of shielding decisions https://t.co/7oayofVjUw https://t.co/mnegorpP1d
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Mashup Score: 21Development and evaluation of a text analytics algorithm for automated application of national COVID-19 shielding criteria in rheumatology patients - 8 month(s) ago
Introduction At the beginning of the COVID-19 pandemic, the UK’s Scientific Committee issued extreme social distancing measures, termed ‘shielding’, aimed at a subpopulation deemed extremely clinically vulnerable to infection. National guidance for risk stratification was based on patients’ age, comorbidities and immunosuppressive therapies, including biologics that are not captured in primary care records. This process required considerable clinician time to manually review outpatient letters. Our aim was to develop and evaluate an automated shielding algorithm by text-mining outpatient letter diagnoses and medications, reducing the need for future manual review. Methods Rheumatology outpatient letters from a large UK foundation trust were retrieved. Free-text diagnoses were processed using Intelligent Medical Objects software (Concept Tagger), which used interface terminology for each condition mapped to Systematized Medical Nomenclature for Medicine–Clinical Terminology (SNOMED-CT)
Source: ard.bmj.comCategories: General Medicine News, RheumatologyTweet-
📣New paper today in @ARD_BMJ Development of a text analytics algorithm for automated application of national #COVID shielding criteria Example of how an #NLP based- algorithm can complement practice & could improve transparency of shielding decisions https://t.co/7oayofVjUw https://t.co/mnegorpP1d
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How common are use of over the counter supplements, pain relief & sleep aids in rheumatology patients? We surveyed ~800 people attending our rheum clinics using 📱💻 >80% took pain relief meds- either OTC, on prescription or borrowed Some insights👇 🔗 https://t.co/aEnkfnhWfN https://t.co/YBoGQG2pHL