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    There is a growing body of evidence that therapy-related myeloid neoplasms (t-MNs) with driver gene mutations arise in the background of clonal hematopoiesis (CH) under the positive selective pressure of chemo- and radiation therapies. Uncovering the exposure relationships that provide selective adv …

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    • We know lenalidomide leads to degradation of IKZF1/3, essential transcription factors in myeloma and tumor suppressors in ALL. Lenalidomide also appears to promote the outgrowth of TP53-mutated HSPCs (see terrific work by Sperling et al. https://t.co/IaYL6r5oWk). (3/x) https://t.co/t83cIDNShc

  • Mashup Score: 0

    There is a growing body of evidence that therapy-related myeloid neoplasms (t-MNs) with driver gene mutations arise in the background of clonal hematopoiesis (CH) under the positive selective pressure of chemo- and radiation therapies. Uncovering the exposure relationships that provide selective adv …

    Tweet Tweets with this article
    • We know lenalidomide leads to degradation of IKZF1/3, essential transcription factors in myeloma and tumor suppressors in ALL. Lenalidomide also appears to promote the outgrowth of TP53-mutated HSPCs (https://t.co/IaYL6r5oWk). (3/x)

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    Behinds the scenes of Carly Rae Jepsen’s Broadway Inspired Music Video for “Surrender My Heart”.#Lenovo #intelevo Listen to The Loneliest Time out now: https…

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    • This may be as close as @CandidCaleb and I get to being "in" a @carlyraejepsen music video, but glad to have been part of "Surrender My Heart" regardless! :) https://t.co/ASVPCCTKJX https://t.co/H6S94zF5zf