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Mashup Score: 5Discovery of Autoantibodies Targeting Nephrin in Minimal... : Journal of the American Society of Nephrology - 2 month(s) ago
-mediated etiology. This study describes the novel discovery in both adults and children with minimal change disease of autoantibodies targeting nephrin, a critical component of the podocyte slit diaphragm that ensures integrity of the glomerular filtration barrier. This observation aligns with the established proteinuric effect of antinephrin antibodies demonstrated in animal models. These findings identify an important autoimmune mechanism in a subset of patients with minimal change disease and provide a framework for the application and development of precision medicine strategies in this condition. Background Failure of the glomerular filtration barrier, primarily by loss of slit diaphragm architecture, underlies nephrotic syndrome in minimal change disease. The etiology remains unknown. The efficacy of B cell–targeted therapies in some patients, together with the known proteinuric effect of anti-nephrin antibodies in rodent models, prompted us to hypothesize that nephrin autoantib
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Mashup Score: 13Advancing parathyroid anatomy understanding through single-cell RNA sequencing in uremic secondary hyperparathyroidism - 2 month(s) ago
This commentary explores the recent application of single-cell RNA sequencing in the study of uremic secondary hyperparathyroidism, shedding light on …
Source: www.sciencedirect.comCategories: General Medicine News, NephrologyTweet
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Mashup Score: 38Cardiac tamponade diagnosed on nephrologist-performed point-of-care ultrasonography - 2 month(s) ago
Author links open overlay panel Aisha Batool 1, Abhilash Koratala 1 All the authors declared no competing interests. AK reports research funding from KidneyCure and the American Society of Nephrology’s William and Sandra Bennett Clinical Scholars Grant. This clinical image complies with the ethical standards outlined in the journal. This case study is not formal research involving human participants or
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Mashup Score: 19Supporters - World Kidney Day 2024 - 2 month(s) ago
We can`t get coordinates for locations: Peru (Post #57701), UK (Post #57700). Please check your API key (you can validate it in maps settings or check in Google Console), make sure Geocoding API is enabled. Supporters globally Supporters globally Our champions World Kidney Day Champions are committed individuals and/or members of kidney foundations, societies of […]
Source: www.worldkidneyday.orgCategories: General Medicine News, NephrologyTweet
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Mashup Score: 20Complement and Podocytopathies: Do We Have a New Biomarker? - 2 month(s) ago
Author links open overlay panel Miquel Blasco 1, Andrew S. Bomback
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Mashup Score: 8Bile cast nephropathy after sinusoidal obstruction syndrome - 2 month(s) ago
Author links open overlay panel Toshiki Terao 1 2, Kyosuke Horikawa 3, Ken-ichi Matsuoka 1 We thank Dr. Wakako Oda (Department of Pathology, Okayama City Hospital, Okayama, Japan) for Hall stain. The authors did not receive financial support from any organization for the submitted
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Mashup Score: 8Determining individual glomerular proteinuria and periglomerular infiltration in a cleared murine kidney by a 3D fast-marching algorithm. - 2 month(s) ago
Three-dimensional imaging has advanced basic research and clinical medicine. However, limited resolution and imperfections of real-world 3D image mate…
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Mashup Score: 41
The use of animal models in therapeutic development has long been the standard practice. However, ethical concerns and the inherent species difference…
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Mashup Score: 5Multi-omics and imaging mass cytometry characterization of human kidneys to identify pathways and phenotypes associated with impaired kidney function. - 3 month(s) ago
Despite the recent advances in our understanding of the role of lipids, metabolites and related enzymes in mediating kidney injury, there is limited i…
Source: www.sciencedirect.comCategories: General Medicine News, NephrologyTweet
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Mashup Score: 49Assessment of epidemiology and outcomes of adult patients with kidney-limited thrombotic microangiopathies. - 3 month(s) ago
Thrombotic microangiopathies (TMA) are usually associated with hematological features (RH-TMA). The epidemiology of TMA limited to kidneys (RL-TMA) is…
Source: www.sciencedirect.comCategories: General Medicine News, NephrologyTweet
4) ↪️Circulating autoantibodies against #nephrin were 🔎identified recently in #minimalchangedisease (MCD). 👉https://t.co/hFDksBNmEk