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Mashup Score: 25Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity - 3 month(s) ago
Photosensitivity is observed in numerous autoimmune diseases and drives poor quality of life and disease flares. Elevated epidermal type I interferon (IFN) production primes for photosensitivity and enhanced inflammation, but the substrates that sustain and amplify this cycle remain undefined. Here, we show that IFN-induced Z-DNA binding protein 1 (ZBP1) stabilizes ultraviolet (UV)B-induced cytosolic Z-DNA derived from oxidized mitochondrial DNA. ZBP1 is significantly upregulated in the epidermis of adult and pediatric patients with autoimmune photosensitivity. Strikingly, lupus keratinocytes accumulate extensive cytosolic Z-DNA after UVB, and transfection of keratinocytes with Z-DNA results in stronger IFN production through cGAS-STING activation compared to B-DNA. ZBP1 knockdown abrogates UV-induced IFN responses, whereas overexpression results in a lupus-like phenotype with spontaneous Z-DNA accumulation and IFN production. Our results highlight Z-DNA and ZBP1 as critical mediators
Source: www.biorxiv.orgCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 2
Aberrant activation of the innate immune system is a known driver of lupus pathogenesis. Inhibition of the inflammasome and its downstream signaling components in murine models of lupus has been shown to reduce the severity of disease. Interleukin-1 beta (IL-1β) is a proinflammatory cytokine released from cells following inflammasome activation. Here, we examine how loss of IL-1β affects disease…
Source: FrontiersCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0ACR Open Rheumatology - 1 year(s) ago
ACR Open Rheumatology, the third official journal of the ACR, will publish clinical, basic, and rehabilitation research in all areas of rheumatology, in a 100% open access format.
Source: www.rheumatology.orgCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0Michigan Medicine - 2 year(s) ago
Description This course will discuss the basics of lupus management and then broaden to discuss management of lupus nephritis, including a discussion of new FDA approved medications. It will also cover efforts to address disparities in lupus care and outcomes and the latest research ongoing to improve our treatment of lupus patients. Target Audience This activity is appropriate for: House…
Source: ww2.highmarksce.comCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0Research Laboratory Tech Sr | U-M Careers - 2 year(s) ago
Apply Now Summary A research technician senior position is available in a productive laboratory at the University of Michigan to study the connections between cutaneous inflammation and autoimmune diseases. Mission Statement Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient…
Source: careers.umich.eduCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 2ANRF 2022 Research Spotlight Webinar Series - Arthritis National Research Foundation | Funding Research To Cure Arthritis - 2 year(s) ago
Education & Resources ANRF 2022 Research Spotlight Webinar Series Register for Webinar Wednesday, October 5, 2022 Rheumatoid Arthritis Proudly Sponsored by: Moderator: Elizabeth Mellins, M.D.Member, ANRF Scientific Advisory BoardProfessor of […]
Categories: Latest Headlines, RheumatologyTweet
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Mashup Score: 8Tofacitinib blocks interferon-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial - PubMed - 2 year(s) ago
This was an investigator-initiated trial designed by the Sponsor and the steering committee. The industry funder, Pfizer, had no role in collecting, analyzing, and interpreting the data. The manuscript was drafted by the authors and was reviewed by Pfizer Inc. before final submission. No medical wri …
Source: PubMedCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0Please wait whilst we redirect you - 2 year(s) ago
About ScienceDirectRemote accessShopping cartAdvertiseContact and supportTerms and conditionsPrivacy policyWe use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies.Copyright © 2022 Elsevier B.V. or its licensors or contributors. ScienceDirect ® is a registered trademark of Elsevier B.V.ScienceDirect ® is a registered…
Source: www.sciencedirect.comCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 1Evaluation of Tofacitinib in Prevention of Photosensitivity in Lupus - Full Text View - ClinicalTrials.gov - 2 year(s) ago
Evaluation of Tofacitinib in Prevention of Photosensitivity in Lupus – Full Text View.
Source: www.clinicaltrials.govCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 4
As the number of physician-scientists continues to decline, action must be taken to support them as they embark on their careers.
Source: Science Translational MedicineCategories: Latest Headlines, RheumatologyTweet
I present new work that we are super proud of. Explains why type I IFNs promote enhanced photosensitivity. Outstanding work by @ben_derm and team!!!! Hopefully reviews will go smoothly! 🤞🏻🤞🏻🤞🏻https://t.co/P02Idmoz8L