• Mashup Score: 2
    RHOJ controls EMT-associated resistance to chemotherapy - Nature - 1 year(s) ago

    RHOJ regulates epithelial-to-mesenchymal-transition-associated resistance to chemotherapy by enhancing the response to replicative stress and activating the DNA damage response, enabling tumour cells to rapidly repair DNA lesions induced by chemotherapy.

    Source: Nature
    Categories: Hem/Oncs, Latest Headlines
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      jsoriamd

      EMT has been associated with #resistance to therapy in #cancer cells. RHOJ, a small GTPase expressed in #EMT cancer cells, controls resistance to therapy by enhancing the response to replicative stress and activating the DNA-damage response. https://t.co/7GQ3XspY8e https://t.co/gAUJvQQPLO

  • Mashup Score: 45
    Programmable protein delivery with a bacterial contractile injection system - Nature - 1 year(s) ago

    The tail fibre of an extracellular contractile injection system (eCIS) from Photorhabdus asymbiotica recognizes targets expressed on eukaryotic host cells, and can be reprogrammed to target specific organisms and cell types for delivery of novel protein payloads.

    Source: Nature
    Categories: Hem/Oncs, Latest Headlines
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      jsoriamd

      Bacterial ‘syringes’ could inject drugs directly into human cells. Discover a programmable system for protein delivery, derived from a molecular injection device found in bacteria, that represents a new biotechnological tool for drug delivery. #ELCC23 https://t.co/r47GI8p9wf https://t.co/Vf87JxK68Z

  • Mashup Score: 10
    Issue: Cancer Cell - 1 year(s) ago

    A holistic view of cancerCancer Cell dedicates this special issue to…not (exclusively) the cancer cell. While understanding maligant cells will always be our foundation and guiding principle, we strongly believe that the most impactful cancer research is currently the one that provides a holistic, systems biology-oriented understanding of the tumor cell and its bidirectional interactions with a…

    Source: www.cell.com
    Categories: Hem/Oncs, Latest Headlines
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      jsoriamd

      A holistic, systems biology-oriented understanding of the tumor cell & its interactions with proximal & distal cells within the organism, is an essential new frontier to improve cancer understanding & therapy. Check out this whole issue on this topic. https://t.co/HFopEdzbM2 https://t.co/JVZeDnl5aT

  • Mashup Score: 3
    For optimal antibody effectiveness, sometimes less is more - 1 year(s) ago

    Modulating receptor-binding affinity influences antibody effectiveness.

    Source: www.nature.com
    Categories: Hem/Oncs, Latest Headlines
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      jsoriamd

      Optimal #antibody effectiveness depends on the level of affinity binding. For blocking antibodies, a high affinity may be most effective. However, for agonist antibodies, recent results suggest that intermediate affinity works best, for #immunotherapy. https://t.co/gvmj87o5ne https://t.co/4pyCY4WT0J

  • Mashup Score: 0
    Human organs-on-chips for disease modelling, drug development and personalized medicine - Nature Reviews Genetics - 1 year(s) ago

    This Review discusses the types of single and multiple human organ-on-a-chip (organ chip) microfluidic devices and their diverse applications for disease modelling, drug development and personalized medicine, as well as the challenges that must be overcome for organ chips to reach their full potential.

    Source: Nature
    Categories: Hem/Oncs, Latest Headlines
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      jsoriamd

      Can single & multiple human organ #chip systems model complex diseases & reproduce human responses to #drugs, #radiation & toxins. Organ-on-a-chip microfluidic culture devices can recapitulate organ-level functions. https://t.co/2oFsL5mUL3 https://t.co/APRpms8UOy

  • Mashup Score: 4
    Protein degraders enter the clinic — a new approach to cancer therapy - Nature Reviews Clinical Oncology - 1 year(s) ago

    Protein degraders constitute a new class of agents that eliminate, rather than just inhibit, their target proteins. These novel agents have recently entered testing in oncology trials, with initial data providing clinical proof of concept for the mechanism of action as well as the antitumour activity of heterobifunctional protein degraders. In this Review, the authors outline the progress in the…

    Source: Nature
    Categories: Hem/Oncs, Latest Headlines
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      jsoriamd

      Protein degraders harnesses the cell’s natural protein-degradation machinery (ubiquitin–proteasome system) to target proteins involved in #cancer. 18 protein degraders are under clinical evaluation in patients with solid tumors & hematological cancers. https://t.co/P6TI8nucN2 https://t.co/Pmz3t4j98A

  • Mashup Score: 153
    Putting bacteria on the cancer map - 1 year(s) ago

    In a study recently in Nature, Galeano Niño et al. use spatial profiling and single-cell RNA sequencing to delineate the spatial organization of microbiota in cancer. Their findings demonstrate that tumor-associated microbiota coalesce in micro-niches where they may mediate immune and epithelial oncogenic roles.

    Source: Immunity
    Categories: Hem/Oncs, Latest Headlines
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    • Profile photo of jsoriamd
      jsoriamd

      Spatial profiling & single-cell RNA sequencing has demonstrated that tumor-associated microbiota coalesce in micro-niches where they may mediate immune & epithelial oncogenic roles. https://t.co/3VgpLUZGcQ https://t.co/yeMgCJlO1E https://t.co/mkOunse7vZ

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