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Mashup Score: 33
Abstract. Small cell lung cancer (SCLC) is a recalcitrant neuroendocrine carcinoma with dismal survival outcomes. A major barrier in the field has been the relative paucity of human tumors studied. Here we provide an integrated analysis of 3,600 “real-world” SCLC cases. This large cohort allowed us to identify new recurrent alterations and genetic subtypes, including STK11-mutant tumors (1.7%)…
Categories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Integrative Pan-Cancer Genomic and Transcriptomic Analyses of Refractory Metastatic Cancer - 1 year(s) ago
AbstractMetastatic relapse after treatment is the leading cause of cancer mortality, and known resistance mechanisms are missing for most treatments administered to patients. To bridge this gap, we analyze a pan-cancer cohort (META-PRISM) of 1,031 refractory metastatic tumors profiled via whole-exome and transcriptome sequencing. META-PRISM tumors, particularly prostate, bladder, and pancreatic…
Categories: Hem/Oncs, Latest HeadlinesTweet-
A cohort of 1,031 tumors resistant to SOC were analyzed by WES & RNAseq. Mutational signatures were observed in platinum treated pts. MSI & high TMB found in 3% & 13% of refractory metastatic cancer patients, what is #imunotherapy value for such patients? https://t.co/7bj1SleiFV https://t.co/jRaUbExt1V
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Mashup Score: 3
This review discusses generalist medical artificial intelligence, identifying potential applications and setting out specific technical capabilities and training datasets necessary to enable them, as well as highlighting challenges to its implementation.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
#ArtificialIntelligence models built through self-supervision on large, diverse datasets, will interpret combinations of medical modalities, including data from imaging, electronic health records, laboratory results, genomics, graphs, or medical text. https://t.co/tG3YfSyqUl https://t.co/96KJg6wMbd
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Mashup Score: 4ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA - Genome Medicine - 1 year(s) ago
Background Liquid biopsies and the dynamic tracking of somatic mutations within circulating tumour DNA (ctDNA) can provide insight into the dynamics of cancer evolution and the intra-tumour heterogeneity that fuels treatment resistance. However, identifying and tracking dynamic changes in somatic copy number alterations (SCNAs), which have been associated with poor outcome and metastasis, using…
Source: BioMed CentralCategories: Hem/Oncs, Latest HeadlinesTweet-
A fascinating paper suggesting that aneuploidy can be measured in ctDNA #liquidbiopsy in #pancreatic #Cancer patients. https://t.co/ywPXW1vOWI https://t.co/IabmmJgjOx
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Mashup Score: 2Pancreatic cancer: Advances and challenges - 1 year(s) ago
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant efforts have largely defined major genetic factors driving P…
Source: www.sciencedirect.comCategories: Hem/Oncs, Latest HeadlinesTweet-
A comprehensive review on #pancreatic #cancer pathogenesis, progression & therapeutic perspectives. https://t.co/HxCMezHcIi https://t.co/81OlUfP9lk
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Mashup Score: 3
Results of the TRACERx study shed new light into the association between body composition and body weight with survival in individuals with non-small cell lung cancer, and delineate potential biological processes and mediators contributing to the development of cancer-associated cachexia.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Cancer-associated cachexia increases morbidity & mortality in cancer. NSCLC with cachexia have inflammatory signaling & EMT pathways, upregulated MAGEA6 & ADAMTS3. Proteomic analysis supports the l therapeutic relevance of targeting GDF15 in cachexia. https://t.co/L6iaFE2LnU https://t.co/q4VMtomBP5
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Mashup Score: 0Evolutionary characterization of lung adenocarcinoma morphology in TRACERx - Nature Medicine - 1 year(s) ago
Analyses of the TRACERx study unveil the relationship between tissue morphology, the underlying evolutionary genomic landscape, and clinical and anatomical relapse risk of lung adenocarcinomas.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
A must read: @CharleSwanton last paper. Packed with exceptional & actionable data. E.g. (1) histological spread through airspace = risk of intra-thoracic recurrence, (2) pre-operative ctDNA detection is associated with extra-thoracic recurrence. https://t.co/71M0pKGsB3 https://t.co/WKCPsWd03A
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Mashup Score: 0
Summary:. The shift in cancer therapy from broadly cytotoxic agents toward “personalized” treatments that target specific alterations in each patient’s tumor requires diagnostic pathology approaches that are quantitative and biospecimen-friendly. Novel multiplexed antibody-based imaging technologies can measure single-cell expression of over 60 proteins in intact tumor sections and hold promise…
Categories: Hem/Oncs, Latest HeadlinesTweet-
Multiplexed antibody-based imaging technologies can quantify 2 to 60+ proteins while preserving spatial information. These approaches might be applied to sections of FFPE patient’s biopsies to guide #immunotherapy, #bispecifics & others. https://t.co/Tuh5NYB1EI https://t.co/QhBPJzGzQH
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Mashup Score: 2RHOJ controls EMT-associated resistance to chemotherapy - Nature - 1 year(s) ago
RHOJ regulates epithelial-to-mesenchymal-transition-associated resistance to chemotherapy by enhancing the response to replicative stress and activating the DNA damage response, enabling tumour cells to rapidly repair DNA lesions induced by chemotherapy.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
EMT has been associated with #resistance to therapy in #cancer cells. RHOJ, a small GTPase expressed in #EMT cancer cells, controls resistance to therapy by enhancing the response to replicative stress and activating the DNA-damage response. https://t.co/7GQ3XspY8e https://t.co/gAUJvQQPLO
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Mashup Score: 45Programmable protein delivery with a bacterial contractile injection system - Nature - 1 year(s) ago
The tail fibre of an extracellular contractile injection system (eCIS) from Photorhabdus asymbiotica recognizes targets expressed on eukaryotic host cells, and can be reprogrammed to target specific organisms and cell types for delivery of novel protein payloads.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Bacterial ‘syringes’ could inject drugs directly into human cells. Discover a programmable system for protein delivery, derived from a molecular injection device found in bacteria, that represents a new biotechnological tool for drug delivery. #ELCC23 https://t.co/r47GI8p9wf https://t.co/Vf87JxK68Z
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Genomic analysis of 3,600 SCLC cases demonstrates frequent alterations in the PTEN pathway in brain metastases, a rare subgroup of TP53/RB1 WT tumors (5.5%), & ultra-rare cases HPV+. 4q12 amp has increased OS , while CCNE1 amp has decreased OS. https://t.co/c1OcDhuUoD https://t.co/bwQZfadV0o