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Mashup Score: 10Acute promyelocytic leukemia with torque teno mini virus (TTMV)::RARA fusion: an approach to screening and diagnosis - 5 hour(s) ago
Acute promyelocytic leukemia (APL) with variant RARA translocation is linked to over 15 partner genes. Recent publications encompassing six cases have expanded the spectrum of RARA partners to torque teno mini virus (TTMV). This entity is likely under-recognized due to lack of clinician and pathologist familiarity, inability to detect the fusion using routine testing modalities, and informatic challenges in its recognition within next-generation sequencing (NGS) data. We describe a clinicopathologic approach and provide necessary tools to screen and diagnose APL with TTMV::RARA using existing clinical DNA or RNA-based NGS assays, which led to identification of four cases, all without other known cytogenetic/molecular drivers.
Source: www.modernpathology.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 35Kikuchi disease with an exuberant proliferation of large T‐cells: a study of 25 cases that can mimic T‐Cell lymphoma - 27 day(s) ago
Kikuchi disease with exuberant T-cell proliferation mimicking T-cell lymphoma: Histologically, sheets of large cells are present associated with karyorrhectic debris. Immunophenotypically, large cell…
Source: onlinelibrary.wiley.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 28Discerning clinicopathological features of congenital neutropenia syndromes: an approach to diagnostically challenging differential diagnoses - 1 month(s) ago
The congenital neutropenia syndromes are rare haematological conditions defined by impaired myeloid precursor differentiation or function. Patients are prone to severe infections with high mortality rates in early life. While some patients benefit from granulocyte colony-stimulating factor treatment, they may still face an increased risk of bone marrow failure, myelodysplastic syndrome and acute leukaemia. Accurate diagnosis is crucial for improved outcomes; however, diagnosis depends on familiarity with a heterogeneous group of rare disorders that remain incompletely characterised. The clinical and pathological overlap between reactive conditions, primary and congenital neutropenias, bone marrow failure, and myelodysplastic syndromes further clouds diagnostic clarity. We review the diagnostically useful clinicopathological and morphological features of reactive causes of neutropenia and the most common primary neutropenia disorders: constitutional/benign ethnic neutropenia, chronic id
Source: jcp.bmj.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 6CXCR4 WHIM syndrome is a cancer predisposition condition for virus-induced malignancies - PubMed - 2 month(s) ago
Warts, hypogammaglobulinaemia, infections and myelokathexis syndrome (WHIMS) is a rare combined primary immunodeficiency caused by the gain of function of the CXCR4 chemokine receptor. We present the prevalence of cancer in WHIMS patients based on data from the French Severe Chronic Neutropenia Regi …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 7Inherited bone marrow failure syndromes and germline predisposition to myeloid neoplasia: A practical approach for the pathologist - PubMed - 4 month(s) ago
The diagnostic work up and surveillance of germline disorders of bone marrow failure and predisposition to myeloid malignancy is complex and involves correlation between clinical findings, laboratory and genetic studies, and bone marrow histopathology. The rarity of these disorders and the overlap o …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0From Salman Rushdie to RuPaul: the books to look out for in 2024 | Books | The Guardian - 4 month(s) ago
Memoirs from Neneh Cherry and Rebel Wilson, Colm Tóibín’s sequel to Brooklyn and a departure for Ali Smith – the biggest fiction and nonfiction for the year ahead
Source: amp.theguardian.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4Natural history study of patients with familial platelet disorder with associated myeloid malignancy - 5 month(s) ago
First report, to our knowledge, of clinical findings from a comprehensive longitudinal natural history study of patients with germ line RUNX1 variants.A total o
Source: ashpublications.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4Natural history study of patients with familial platelet disorder with associated myeloid malignancy - 5 month(s) ago
First report, to our knowledge, of clinical findings from a comprehensive longitudinal natural history study of patients with germ line RUNX1 variants.A total o
Source: ashpublications.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 11IGJ and SPATS2L immunohistochemistry sensitively and specifically identify BCR::ABL1+ and BCR::ABL1‐like B‐acute lymphoblastic leukaemia - 7 month(s) ago
An official journal of the British Society for Haematology, the British Journal of Haematology offers high visibility for clinical, basic and translational research.
Source: onlinelibrary.wiley.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 9Inherited bone marrow failure syndromes and germline predisposition to myeloid neoplasia: A practical approach for the pathologist - 9 month(s) ago
The diagnostic work up and surveillance of germline disorders of bone marrow failure and predisposition to myeloid malignancy is complex and involves …
Source: www.sciencedirect.comCategories: Hem/Oncs, Latest HeadlinesTweet
Have you ever had a case you were very suspicious was acute promyelocytic leukemia, but all RARA testing was negative? It could be APML with torque teno mini virus (TTMV)::RARA fusion. #hemepath #pathtwitter #hemeonc #hematology https://t.co/haGN3wIF7h