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Mashup Score: 1
In BriefThis study screens 21,000 autoantibodies in aNSCLC patients undergoing ICIs monotherapy and chemoimmunotherapy, identifying prognostic markers—MAX, DHX29, and TAPBP AAbs—for early progression and progression-free survival. This systematic approach involves de novo screening, identification, and validation, providing clinical potential to monitor chemoimmunotherapy efficacy and detect disease progression.
Source: www.mcponline.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 0American Journal of Transplantation - 5 day(s) ago
Nadim Mahmud, MD MS MPH MSCE Assistant Professor Hospital of the University of Pennsylvania, Philadelphia, PA, USA William Bernal, MD MS MPH MSCE Professor King’s College Hospital, London, UK Salvatore Piano, MD, PhD Assistant Professor MD MS MPH MSCE King’s College Hospital, London, UK This virtual issue delves into the multifaceted realm of Acute-on-Chronic Liver Failure (ACLF), a condition with extremely high short-term mortality that requires expert management and often consideration of liver transplan
Source: www.amjtransplant.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 118th Vaccine Congress About - 8 day(s) ago
The 18th Vaccine Congress will be held at the Riva Del Garda Congress Centre on the northern shores of famous Lake Garda
Source: www.elsevier.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 118th Vaccine Congress About - 17 day(s) ago
The 18th Vaccine Congress will be held at the Riva Del Garda Congress Centre on the northern shores of famous Lake Garda
Source: www.elsevier.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 1
Sterile alpha and HEAT/Armadillo motif-containing protein (SARM1) was recently described as a NAD+-consuming enzyme, and has previously been shown to regulate immune responses in macrophages. Neuronal SARM1 is known to contribute to axon degeneration due to its NADase activity. However, how SARM1 affects macrophage metabolism has not been explored. Here, we show that macrophages from Sarm1-/- mice display elevated NAD+ concentrations and lower cyclic ADPR, a known product of SARM1-dependent NAD+ catabolism.
Source: www.jbc.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 1Truncation of the constant domain drives amyloid formation by immunoglobulin light chains - 23 day(s) ago
AL amyloidosis is a life-threatening disease caused by deposition of immunoglobulin light chains. While the mechanisms underlying light chains amyloidogenesis in vivo remain unclear, several studies have highlighted the role that tissue environment and structural amyloidogenicity of individual light chains have in the disease pathogenesis. AL natural deposits contain both full-length light chains and fragments encompassing the variable domain (VL) as well as different length segments of the constant region (CL), thus highlighting the relevance that proteolysis may have in the fibrillogenesis pathway.
Source: www.jbc.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 118th Vaccine Congress About - 24 day(s) ago
The 18th Vaccine Congress will be held at the Riva Del Garda Congress Centre on the northern shores of famous Lake Garda
Source: www.elsevier.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 0HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent - 25 day(s) ago
The inflammasome is a large multiprotein complex that assembles in the cell cytoplasm in response to stress or pathogenic infection. Its primary function is to defend the cell and promote the secretion of pro-inflammatory cytokines, including IL-1β and IL-18. Previous research has shown that in immortalized bone marrow-derived macrophages (iBMDMs) inflammasome assembly is dependent on the deacetylase HDAC6 and the aggresome processing pathway (APP), a cellular pathway involved in the disposal of misfolded proteins.
Source: www.jbc.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 3Alternative autophagy dampens UVB-induced NLRP3 inflammasome activation in human keratinocytes - 27 day(s) ago
Sunlight exposure results in an inflammatory reaction of the skin commonly known as sunburn, which increases skin cancer risk. In particular, the ultraviolet B (UVB) component of sunlight induces inflammasome activation in keratinocytes to instigate the cutaneous inflammatory responses. Here, we explore the intracellular machinery that maintains skin homeostasis by suppressing UVB-induced inflammasome activation in human keratinocytes. We found that pharmacological inhibition of autophagy promoted UVB-induced NLRP3 inflammasome activation.
Source: www.jbc.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 118th Vaccine Congress About - 1 month(s) ago
The 18th Vaccine Congress will be held at the Riva Del Garda Congress Centre on the northern shores of famous Lake Garda
Source: www.elsevier.comCategories: General Medicine News, Allergy-ImmunologyTweet
Dai et al.'s results present a longitudinal analysis of changes in prognostic AAbs in aNSCLC patients undergoing chemoimmunotherapy. https://t.co/NzQ3TcK1Zj