-
Mashup Score: 63Biomarkers of Efficacy and Safety of the Academic BCMA-CART ARI0002h for the Treatment of Refractory Multiple Myeloma - 26 day(s) ago
AbstractPurpose:. B-cell maturation antigen (BCMA)-chimeric antigen receptor T-cells (CART) improve results obtained with conventional therapy in the treatment of relapsed/refractory multiple myeloma. However, the high demand and expensive costs associated with CART therapy might prove unsustainable for health systems. Academic CARTs could potentially overcome these issues. Moreover, response biomarkers and resistance mechanisms need to be identified and addressed to improve efficacy and patient selection. Here, we present clinical and ancillary results of the 60 patients treated with the academic BCMA-CART, ARI0002h, in the CARTBCMA-HCB-01 trial.Patients and Methods:. We collected apheresis, final product, peripheral blood and bone marrow samples before and after infusion. We assessed BCMA, T-cell subsets, CART kinetics and antibodies, B-cell aplasia, cytokines, and measurable residual disease by next-generation flow cytometry, and correlated these to clinical outcomes.Results:. At cu
Source: aacrjournals.orgCategories: General Medicine News, Hematologists1Tweet
-
Mashup Score: 5
Dirigido a: Médicos, fundamentalmente hematólogos, nefrólogos e internistas, implicados en el diagnóstico y tratamiento de pacientes afectos de amiloidosis y/o mieloma múltiple. Aunque el curso está abierto a todos los profesionales mencionados anteriormente, creemos que el mayor beneficio lo pueden obtener los que ya tienen cierta experiencia con este tipo de pacientes. Objetivos: Efectuar una…
Source: www.aulaclinic.comCategories: Hematologists1, Latest HeadlinesTweet
-
Mashup Score: 1Myeloma Collection | Blood Cancer Discovery | American Association for Cancer Research - 1 year(s) ago
The Blood Cancer Discovery editors proudly present this collection of impactful myeloma articles that have been published in the Journal.
Source: aacrjournals.orgCategories: Hematologists1, Latest HeadlinesTweet
-
Mashup Score: 2Bolsa de empleo - 1 year(s) ago
SEHH – Sociedad Española de Hematología y Hemoterapia
Source: www.sehh.esCategories: Hematologists1, Latest HeadlinesTweet
-
Mashup Score: 3
La Universidad de Barcelona dispone una nueva cátedra la Cátedra UB AMGEN de Mieloma Múltiple
Source: IM MedicoCategories: Hematologists1, Latest HeadlinesTweet
-
Mashup Score: 4Shibboleth Authentication Request - 2 year(s) ago
If your browser does not continue automatically, click
Source: login.sire.ub.eduCategories: Hematologists1, Latest HeadlinesTweet
-
Mashup Score: 2The Physician-Scientist Career Chronicles: From MD to PhD - 2 year(s) ago
L’esdeveniment “The Physician-Scientist Career Chronicles: From MD to PhD” està organitzat pel Centre de Regulació Genòmica (CRG) i l’Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) dins el marc del Programa EMERALD, el primer programa de doctorat per a metges europeus. Formarà pa
Source: Clínic BarcelonaCategories: Hematologists1, Latest HeadlinesTweet
-
Mashup Score: 2ATRA works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T-cells - 2 year(s) ago
B-cell maturation antigen (BCMA) is the lead antigen for CAR T-cell therapy in multiple myeloma (MM). A challenge is inter- and intra-patient heterogeneity in BCMA expression on MM cells and BCMA downmodulation under therapeutic pressure. Accordingly, there is a desire to augment and sustain BCMA expression on MM cells in patients that receive BCMA-CAR T-cell therapy. We used all-trans retinoic…
Source: rev.vuCategories: Hematologists1, Latest HeadlinesTweet
-
Mashup Score: 1
El IDIBAPS impulsa varios programas para facilitar que profesionales asistenciales compaginen la atención a los enfermos con la investigación biomédica o disfruten de períodos de dedicación intensiva a la investigación.
Source: Clínic BarcelonaCategories: Hematologists1, Latest HeadlinesTweet
-
Mashup Score: 1Immunotherapy Collection | Blood Cancer Discovery | American Association for Cancer Research - 2 year(s) ago
The collection showcases recent advances published in Blood Cancer Discovery on immunotherapy. This research holds promise to enhance clinical benefit
Source: aacrjournals.orgCategories: Hematologists1, Latest HeadlinesTweet
Biomarkers of Efficacy and Safety of the Academic BCMA-CART ARI0002h for the Treatment of Refractory Multiple Myeloma https://t.co/sx8x9di0eL