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Mashup Score: 8
Key PointsDespite having relatively favorable disease kinetics, patients with relapsed/refractory BL who receive CAR T cells have poor outcomes.Future tria
Source: ashpublications.orgCategories: General Medicine NewsTweet
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Mashup Score: 28
Patients with relapsed or refractory (r/r) primary central nervous system (CNS) lymphoma (PCNSL) or secondary central nervous system (CNS) lymphoma (SCNSL) face a dismal prognosis. They have been exc…
Source: onlinelibrary.wiley.comCategories: General Medicine NewsTweet
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Mashup Score: 5
Gait speed and grip strength are widely used measures of physical function in older adults and are predictive of disability, hospitalization, and mortality. However, there is a limited understanding of the long-term trajectories of these measures and which older adults are at the highest risk of functional decline. We used data from the National Health and Aging Trends Study (NHATS) to identify subgroups of community-dwelling older adults with distinct 10-year trajectories in gait speed and grip strength and to examine the baseline factors associated with these patterns. The sample included 4961 adults aged 65 years and older who completed gait speed and grip strength assessments in 2011 and at least one subsequent wave between 2013 and 2021. Using latent class growth analysis, we identified three trajectories for each measure: worsening, stable, and improving. More than one-third of participants were in the worsening group for at least one measure. In multinomial logistic regression m
Source: www.mdpi.comCategories: General Medicine NewsTweet
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Mashup Score: 5
¿Es la sangre un órgano? ¿Qué puede contar de nuestra salud? En esta entrega de El Catalizador emprendemos un viaje para conocer qué hay dentro de la sangre …
Source: www.youtube.comCategories: General Medicine NewsTweet
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Mashup Score: 40Brentuximab Vedotin Plus Chemo Wins EU Approval for Newly Diagnosed, Stage IIB-IV Hodgkin Lymphoma - 3 day(s) ago
Brentuximab vedotin plus ECADD chemotherapy has been approved in Europe for adult patients with newly diagnosed, stage IIB to IV Hodgkin lymphoma.
Source: www.onclive.comCategories: General Medicine NewsTweet
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Mashup Score: 51When and How Long to Treat Chronic Lymphocytic Leukemia? - 13 day(s) ago
Chronic lymphocytic leukemia (CLL) remains an incurable disease, except in rare cases treated with allogeneic stem-cell transplantation or favorable-risk CLL treated with chemoimmunotherapy. Treatment initiation follows the Rai and Binet staging systems, …
Source: ascopubs.orgCategories: General Medicine NewsTweet
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Mashup Score: 5A new clinical age of aging research - 14 day(s) ago
Aging is a major risk factor for a variety of diseases, thus, translation of aging research into practical applications is driven by the unmet need for existing clinical therapeutic options. Basic and translational research efforts are converging at a critical stage, yielding insights into how fundamental aging mechanisms are used to identify promising geroprotectors or therapeutics. This review highlights several research areas from a clinical perspective, including senescent cell targeting, alleviation of inflammaging, and optimization of metabolism with endogenous metabolites or precursors. Refining our understanding of these key areas, especially from the clinical angle, may help us to better understand and attenuate aging processes and improve overall health outcomes.
Source: www.cell.comCategories: General Medicine NewsTweet
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Mashup Score: 19Adjusting the scope of natural killer cells in cancer therapy - 14 day(s) ago
Cellular & Molecular Immunology – Adjusting the scope of natural killer cells in cancer therapy
Source: www.nature.comCategories: General Medicine NewsTweet
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Mashup Score: 1The Role of Aging and Senescence in Immune Checkpoint Inhibitor Response and Toxicity - 16 day(s) ago
Cellular senescence accumulates with age and has been shown to impact numerous physiological and pathological processes, including immune function. The role of cellular senescence in cancer is multifaceted, but the impact on immune checkpoint inhibitor response and toxicity has not been fully evaluated. In this review, we evaluate the impact of cellular senescence in various biological compartments, including the tumor, the tumor microenvironment, and the immune system, on immune checkpoint inhibitor efficacy and toxicity. We provide an overview of the impact of cellular senescence in normal and pathological contexts and examine recent studies that have connected aging and cellular senescence to immune checkpoint inhibitor treatment in both the pre-clinical and clinical contexts. Overall, senescence plays a multi-faceted, context-specific role and has been shown to modulate immune-related adverse event incidence as well as immune checkpoint inhibitor response.
Source: www.mdpi.comCategories: General Medicine NewsTweet
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Mashup Score: 0Impact of immunosenescence and inflammaging on the effects of immune checkpoint inhibitors - 16 day(s) ago
Immune checkpoint inhibitors (ICIs) are employed in immunotherapeutic applications for patients with weakened immune systems and can improve the ability of T cells to kill cancer cells. Although ICIs can potentially treat different types of cancers …
Source: pmc.ncbi.nlm.nih.govCategories: General Medicine NewsTweet
#Hematology Outcomes among adult recipients of #CARTcell therapy for #Burkitt #lymphoma | Blood | American Society of Hematology #lymsm https://t.co/1NzFZfx95i