• Mashup Score: 5

    Gait speed and grip strength are widely used measures of physical function in older adults and are predictive of disability, hospitalization, and mortality. However, there is a limited understanding of the long-term trajectories of these measures and which older adults are at the highest risk of functional decline. We used data from the National Health and Aging Trends Study (NHATS) to identify subgroups of community-dwelling older adults with distinct 10-year trajectories in gait speed and grip strength and to examine the baseline factors associated with these patterns. The sample included 4961 adults aged 65 years and older who completed gait speed and grip strength assessments in 2011 and at least one subsequent wave between 2013 and 2021. Using latent class growth analysis, we identified three trajectories for each measure: worsening, stable, and improving. More than one-third of participants were in the worsening group for at least one measure. In multinomial logistic regression m

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    • Identifying Older Adults at Risk of Accelerated Decline in Gait Speed and Grip Strength: Insights from the National Health and Aging Trends Study (NHATS) #aging #ageing #frailty https://t.co/bVMoFN88lb

  • Mashup Score: 5

    ¿Es la sangre un órgano? ¿Qué puede contar de nuestra salud? En esta entrega de El Catalizador emprendemos un viaje para conocer qué hay dentro de la sangre …

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    • El Catalizador 2X04 - #Innovación y #Hematología Hablamos con @CesarVelascoMun y @DraPascual sobre cómo los avances tecnológicos abren nuevas oportunidades para el diagnóstico 🔬 y el tratamiento personalizado 💊 de las enfermedades de la sangre 🩸. 🔗 https://t.co/LU0uSuNARK

  • Mashup Score: 51

    Chronic lymphocytic leukemia (CLL) remains an incurable disease, except in rare cases treated with allogeneic stem-cell transplantation or favorable-risk CLL treated with chemoimmunotherapy. Treatment initiation follows the Rai and Binet staging systems, …

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    • #Hematology When and How Long to Treat Chronic Lymphocytic Leukemia #CLL? | American Society of Clinical Oncology Educational Book ⁦@ASCO⁩ #ASCO2025 #ASCO25 #lymsm #leusm #CLLsm https://t.co/aMp1NjNdzo

  • Mashup Score: 5

    Aging is a major risk factor for a variety of diseases, thus, translation of aging research into practical applications is driven by the unmet need for existing clinical therapeutic options. Basic and translational research efforts are converging at a critical stage, yielding insights into how fundamental aging mechanisms are used to identify promising geroprotectors or therapeutics. This review highlights several research areas from a clinical perspective, including senescent cell targeting, alleviation of inflammaging, and optimization of metabolism with endogenous metabolites or precursors. Refining our understanding of these key areas, especially from the clinical angle, may help us to better understand and attenuate aging processes and improve overall health outcomes.

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    • RT @agingdoc1: A new clinical age of aging research https://t.co/2liEL4uSsA https://t.co/btIdf1X8hZ

  • Mashup Score: 1

    Cellular senescence accumulates with age and has been shown to impact numerous physiological and pathological processes, including immune function. The role of cellular senescence in cancer is multifaceted, but the impact on immune checkpoint inhibitor response and toxicity has not been fully evaluated. In this review, we evaluate the impact of cellular senescence in various biological compartments, including the tumor, the tumor microenvironment, and the immune system, on immune checkpoint inhibitor efficacy and toxicity. We provide an overview of the impact of cellular senescence in normal and pathological contexts and examine recent studies that have connected aging and cellular senescence to immune checkpoint inhibitor treatment in both the pre-clinical and clinical contexts. Overall, senescence plays a multi-faceted, context-specific role and has been shown to modulate immune-related adverse event incidence as well as immune checkpoint inhibitor response.

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    • The Role of #Aging and #Senescence in Immune Checkpoint Inhibitor Response and Toxicity https://t.co/13O59u1DR3 #ImmunoOnc #gerionc #geriheme