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Mashup Score: 4Personal Information - Advances in Genitourinary Oncology - 29 day(s) ago
Cancers of the genitourinary tract represent some of the most commonly diagnosed cancers in the United States. In 2023, over 440,000 patients will be diagnosed with . Online registration by Cvent
Source: web.cvent.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 162023 NYCM: Christopher Barbieri - - 7 month(s) ago
I’m fundraising for the NYP SPORE Fund at NewYork-Presbyterian.
Source: give.nyp.orgCategories: Latest Headlines, Oncologists1Tweet-
In just a few weeks I'll be running the NYC marathon to raise funds for prostate cancer research! Every dollar goes to support community outreach, clinical trials, and translational research: https://t.co/LrDwnKCxPk
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Mashup Score: 1prostate cancer androgen receptor cistrome in African American men associates with upregulation of lipid metabolism and immune response - 2 year(s) ago
Abstract. African American (AA) men are more likely to be diagnosed with and die from prostate cancer (PCa) than European American (EA) men. Despite the central role of the androgen receptor (AR) transcription factor in PCa, little is known about the contribution of epigenetics to observed racial disparities. We performed AR ChIP-seq on primary prostate tumors from AA and EA men, finding that…
Categories: Hem/Oncs, Latest HeadlinesTweet-
RT @AmitK_Dash: I feel happy and excited to share our recently published study in Cancer Research @CR_AACR. https://t.co/OhoFDzvUiN
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Mashup Score: 32022 NYCM: Dr. Himanshu Nagar - - 2 year(s) ago
Team:Anderson AklyLuigi MarchionniTimothy McClureDanielle MurtaghHimanshu NagarAndrea SbonerPankaj SharmaWhile we train and run the 2022 NYC Marathon (https://www.nyrr.org/tcsnycmarathon), we would like to invite you to contribute to our fundraising campaign for men’s health awareness and prostate cancer research.Every dollar raised will go directly to men’s health awareness and prostate cancer…
Source: give.nyp.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
Donate here: https://t.co/0WHEAezK3h @TimMcClureMD @asbonerw @marchionniLab https://t.co/Uvk5urRwLR
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RT @HimanshuNagarMD: Donate here: https://t.co/0WHEAezK3h @TimMcClureMD @asbonerw @marchionniLab https://t.co/Uvk5urRwLR
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Mashup Score: 2G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer - Nature Communications - 2 year(s) ago
SPOP functions as a tumour suppressor in prostate cancer but how the protein is regulated is unclear. Here, the authors identify G3BP1 as a competitive inhibitor of SPOP and show that G3BP1-SPOP axis activates androgen signalling to drive tumorigenesis.
Source: Nature CommunicationsCategories: Latest Headlines, UrologyTweet-
RT @Kaochar2: We know so little about how SPOP itself is regulated. Very nice story! https://t.co/73RRTH4GS1 https://t.co/73RRTH4GS1
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Mashup Score: 24Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity - 3 year(s) ago
Grbesa et al. use multilevel epigenomic and transcriptional profiling to characterize genetically normal prostate organoids and show the impact of an early cancer driver (SPOP mutation). Integrative analysis identifies transcriptional programs that are AR regulated and reprogrammed by SPOP mutation, suggesting a basis for enhanced sensitivity to AR-targeting therapies.
Source: Cell ReportsCategories: Latest Headlines, Oncologists1Tweet-
Proud of this great work by Ivana Grbesa @augelloma @deli_liu and many others defining AR chromatin landscape in normal prostate cells and impact of SPOP mutations. Thanks to all collaborators! Tweetorial to follow! @PCF_Science @DamonRunyon https://t.co/XN3nzi6kA0
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Mashup Score: 23Sperm Parameters Before and After COVID-19 mRNA Vaccination - 3 year(s) ago
To address vaccine hesitancy based on concerns about fertility, this study assesses sperm parameters before and after mRNA vaccine administration.
Source: jamanetwork.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @ranjithramamd: Our study in @JAMA_current showed that sperm counts were maintained after #COVIDvaccine https://t.co/bC34U8aHy4 Study…
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Mashup Score: 61JCI - Tumor subtype defines distinct pathways of molecular and clinical progression in primary prostate cancer - 3 year(s) ago
Clinical MedicineGeneticsOncology Free access | 10.1172/JCI147878 Michael A. Augello,1,2 Ivana Grbesa,1,2 Davide Prandi,5 Yang Liu,6 Jonathan E. Shoag,2,7,8 R. Jeffrey Karnes,9 Bruce J. Trock,10 Eric A. Klein,11 Robert B. Den,12 Francesca Demichelis,13 Elai Davicioni,6 Andrea Sboner,1,3,4,14…
Source: www.jci.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
Excited for our most recent work published in JCI https://t.co/BFmpiqk0EZ, showing different modes of molecular and clinical progression in distinct molecular subtypes of prostate cancer. A tweetorial thread --> 1/n https://t.co/lkDzjFXJWP
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Mashup Score: 1Impact of the SPOP Mutant Subtype on the Interpretation of Clinical Parameters in Prostate Cancer - 3 year(s) ago
Purpose Molecular characterization of prostate cancer, including The Cancer Genome Atlas, has revealed distinct subtypes with underlying genomic alterations. One of these core subtypes, SPOP (speckle-type POZ protein) mutant prostate cancer, has previously only been identifiable via DNA sequencing, which has made the impact on prognosis and routinely used risk stratification parameters unclear….
Source: JCO Precision OncologyCategories: Hem/Oncs, Latest HeadlinesTweet-
8/ Next, we developed machine-learning classifiers to predict subtype and early/late status from transcriptional data, using 4 categories: ERG or SPOP (early), and PTEN or CHD1 (late), in an approach we’ve used before https://t.co/OBR84UTVAb. https://t.co/k3oenm9nlL
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Mashup Score: 4SPOP mutation confers sensitivity to AR-targeted therapy in prostate cancer by reshaping the androgen-driven chromatin landscape - 3 year(s) ago
The normal androgen receptor (AR) cistrome and transcriptional program are fundamentally altered in prostate cancer (PCa). Here, we show that SPOP mutations, an early event in prostate tumorigenesis, reshape the chromatin landscape and AR-directed transcriptional program in normal prostate cells. Induction of SPOP mutation results in DNA accessibility and AR binding patterns found in human PCa….
Source: bioRxivCategories: Hem/Oncs, Latest HeadlinesTweet-
Excited to share our latest work profiling the epigenomic and transcriptional impact of SPOP mutations in normal prostate cells - terrific job by Ivana Grbesa and the rest of the team! https://t.co/3XzpInCjAi
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RT @ColumbiaUrology: Register now for this upcoming CME course on cutting edge treatments in GU oncology 🦀. https://t.co/HgagDVzRWM Featu…