-
Mashup Score: 14
COVID-19 trends remain far below levels seen at this time last year, but the numbers are ticking upwards.
Source: www.cbsnews.comCategories: Hem/Oncs, Latest HeadlinesTweet
-
Mashup Score: 8How the Y chromosome makes some cancers more deadly for men - 2 year(s) ago
Two studies help to explain why colorectal and bladder tumours take a bigger toll on men than on women
Source: www.nature.comCategories: Latest Headlines, Oncologists1Tweet-
RT @RonDePinho: How the Y chromosome makes some cancers more deadly for men. https://t.co/5xhSaD90hn
-
-
Mashup Score: 0Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma - 2 year(s) ago
Background Immune responses against tumors are subject to negative feedback regulation. Immune checkpoint inhibitors (ICIs) blocking Programmed cell death protein 1 (PD-1), a receptor expressed on T cells, or its ligand PD-L1 have significantly improved the treatment of cancer, in particular malignant melanoma. Nevertheless, responses and durability are variables, suggesting that additional…
Categories: Hem/Oncs, Latest HeadlinesTweet-
JITC: "Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma" In a UPCI GWAS of adj IFN-a for melanoma, our stat sig SNP for RFS involved glucocorticoid signaling as well (unpublished) https://t.co/icVAIMJ09f
-
-
Mashup Score: 0Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study - 2 year(s) ago
Not all mutations related to TMB-H can enhance antitumour immune response. More composite biomarkers should be investigated (eg, mTMB signature) to tailor treatment with immune checkpoint inhibitors. Our data also provide novel insights for the combination of immune checkpoint inhibitors and drugs targeting cyclin D1 or FGFs.
Source: The Lancet OncologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Reading this paper by Wang et al in @TheLancetOncol about mutational analysis and immune response in TMB-H, very happy to see the discussion moving past the low-hanging fruit. Complex systems can't be addressed with simplistic approaches https://t.co/NmmknOqBpL
-
-
Mashup Score: 29Extensions to the Grammar of Graphics - 2 year(s) ago
ggpp
Source: docs.r4photobiology.infoCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @tjmahr: oh that's slick https://t.co/JF3jDorI0M https://t.co/MgiocyJRkL
-
-
Mashup Score: 0The case of Robert Penman’s tumour - 2 year(s) ago
At the age of 16, Robert Penman presented to a local surgeon with an egg sized tumour in his lower jaw. The connecting teeth were excised, nevertheless, over time, the growth grew rapidly and was l…
Source: The Anatomy LabCategories: Hem/Oncs, Latest HeadlinesTweet-
More details here: https://t.co/siZAWFkGVF https://t.co/N8re1ttKkc
-
-
Mashup Score: 2Severe multi-year drought coincident with Hittite collapse around 1198–1196 bc - Nature - 2 year(s) ago
Tree-ring analysis is correlated with stable isotope data and historical texts to identify an unusual multi-year period of drought from around 1198 to 1196 bc associated with the collapse of the Hittite Empire.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @iosif_lazaridis: https://t.co/wJB8SpO0G9
-
-
Mashup Score: 0
Immune activation can be damaging if responses are not adequately controlled. Schuster et al. reveal that following cytomegalovirus infection, circulating natural killer cells are recruited into non-lymphoid tissues, including the salivary glands, where they establish a tissue-resident, memory-like population that prevents immune-mediated damage and safeguards tissue health by preventing…
Source: ImmunityCategories: Hem/Oncs, Latest HeadlinesTweet-
Autoimmunity regulation via NK cells https://t.co/9FERp80yNH
-
-
Mashup Score: 3
/PRNewswire/ — Marengo Therapeutics, Inc., a company pioneering novel therapeutics targeting the T cell receptor (TCR) Vβ to selectively activate the right T…
Source: www.prnewswire.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @gulleyj1: Delighted to be a part of theirs along with others. https://t.co/6KmtY9MMju
-
-
Mashup Score: 0Pink Sheet - Project Pragmatica: US FDA’s OCE Initiative Aims To Encourage Simple Clinical Trials - Friends of Cancer Research - 2 year(s) ago
Richard Pazdur likely did not surprise anyone when he complained to Friends of Cancer Research Annual Meeting attendees that oncology clinical trials are too complicated. But the director of the US Food and Drug Administration’s Oncology Center of Excellence got a few laughs when he announced his solution. “Well of course we have to launch…
Source: Friends of Cancer ResearchCategories: Hem/Oncs, Latest HeadlinesTweet-
"Project Pragmatica" from the FDA with interesting points here, to address the complexity in trials: "single endpoint, OS", less safety reporting. Not for early phase trials (though not clearly articulated in the article). https://t.co/5vUyRiDQ8a
-
https://t.co/p34T2Cffne @karz