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Mashup Score: 2Neoadjuvant chemotherapy enhances tumor‐specific T cell immunity in patients with HPV‐associated oropharyngeal cancer - 21 day(s) ago
Background Treatment of patients with newly diagnosed HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) with neoadjuvant chemotherapy (NAC) results in a high rate of 5-year recurrence fre…
Source: onlinelibrary.wiley.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 17Risk of recurrence after neoadjuvant chemotherapy and transoral robotic surgery in patients with oropharynx cancer that avoid adjuvant radiation - 21 day(s) ago
Cancer Medicine is an open access, broad-scope oncology journal covering clinical cancer research, cancer biology, cancer prevention, & bioinformatics.
Source: onlinelibrary.wiley.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3
This open access book is a comprehensive guide to how artificial intelligence and machine learning techniques are and can be applied in health care
Source: link.springer.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 19Comparison of Large Language Models in Answering Immuno-Oncology Questions: A Cross-Sectional Study - 2 month(s) ago
This cross-sectional study assessed the ability of ChatGPT-4, ChatGPT-3.5, and Google Bard to answer questions related to immuno-oncology.
Source: academic.oup.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 17Comparison of Large Language Models in Answering Immuno-Oncology Questions: A Cross-Sectional Study - 3 month(s) ago
This cross-sectional study assessed the ability of ChatGPT-4, ChatGPT-3.5, and Google Bard to answer questions related to immuno-oncology.
Source: academic.oup.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4
This extensive description of a unique cohort of paediatric patients with Cushing syndrome has the potential to inform diagnostic workup, preventative actions, and follow-up of children with this rare endocrine condition.
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 7
Background: Artificial intelligence is increasingly being applied to many workflows. Large language models (LLMs) are publicly accessible platforms trained to understand, interact with, and…
Source: preprints.jmir.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 2Mutation of NOTCH1 is selected within normal esophageal tissues, yet leads to selective epistasis suppressive of further evolution into cancer - 6 month(s) ago
Sequencing of tissues from histologically normal esophagus, among other organs, has revealed that normal tissues harbor somatic variants that are also found in cancers arising from the same tissue types. Our understanding of how somatic mutations commonly found in normal tissue can contribute to tumorigenesis is limited: common somatic mutations may or may not confer phenotypes compatible with oncogenesis. However, the strength of selection for somatic variants that appear in both normal and cancer tissues can be quantified in each context using evolutionary modeling approaches. We studied the evolutionary trajectory from normal esophageal tissue to esophageal squamous-cell carcinoma (ESCC) by analysis of 2171 sequenced samples from previous studies on normal esophageal epithelium and ESCC to reveal the stepwise contributions of somatic mutations to increased cellular division and survival. We also analyzed pairwise selective epistasis between somatically mutated genes that may lead to
Source: www.biorxiv.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2Building Transparent ML/AI Solutions to Advance Biological Research Codeathon - NCBI Insights - 6 month(s) ago
Machine Learning and Artificial Intelligence (ML/AI) Codeathon to Advance Biological Research- This codeathon invites developers and tech enthusiasts with a passion for social good to build equitable and transparent ML/AI solutions that tackle various problems in healthcare, research, education, and more. The event will be held virtually from February 26th to March 1st, 2024 (11 AM- 5 PM ET). Participants will have the opportunity to network with fellow participants and learn from experts in industry, academia, and government. The codeathon will be cooperative rather than competitive, and teams will share ideas and technical expertise. At the end of the event, teams will present their work to each other, representatives from the NIH, and the public. After the codeathon, the team products will be made publicly available through the NCBI Codeathons GitHub Organization and may be featured on NCBI sites. Participants are encouraged to co-author a joint manuscript and share their work onlin
Source: ncbiinsights.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 20Comparison of Large Language Models in Answering Immuno-Oncology Questions: A Cross-Sectional Study - 6 month(s) ago
Background: The capability of large language models (LLMs) to understand and generate human-readable text has prompted the investigation of their potential as educational and management tools for cancer patients and healthcare providers. Materials and Methods: We conducted a cross-sectional study aimed at evaluating the ability of ChatGPT-4, ChatGPT-3.5, and Google Bard to answer questions related to four domains of immuno-oncology (Mechanisms, Indications, Toxicities, and Prognosis). We generated 60 open-ended questions (15 for each section). Questions were manually submitted to LLMs, and responses were collected on June 30th, 2023. Two reviewers evaluated the answers independently. Results: ChatGPT-4 and ChatGPT-3.5 answered all questions, whereas Google Bard answered only 53.3% (p <0.0001). The number of questions with reproducible answers was higher for ChatGPT-4 (95%) and ChatGPT3.5 (88.3%) than for Google Bard (50%) (p <0.0001). In terms of accuracy, the number of answers deemed
Source: www.medrxiv.orgCategories: General Medicine News, Hem/OncsTweet
Previous related work by the Allen Lab @NCIResearchCtr has shown that neoadjuvant chemotherapy induces HPV-specific tumor T cell responses. https://t.co/CxQWAFCINE