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Mashup Score: 31Chromophobe renal cell carcinoma - 14 day(s) ago
Chromophobe renal cell carcinoma (ChRCC) is the second most common variant histology (non-clear cell) RCC. ChRCC is distinct from clear cell RCC (ccRCC) in terms of genetics, genomics, metabolism, cell of origin, and response to targeted and immune therapies. The pathogenesis of ChRCC remains unclear, but current data suggest two potential mechanisms: mTORC1 hyperactivation through PTEN pathway mutations and mitochondrial dysfunction leading to oxidative stress. There are no specific approved treatments for ChRCC, although some responses to tyrosine kinase and mTOR inhibitors have been observed. Response to immunotherapy is generally limited. Targetable pathways involving innate lymphoid cells/IL-15 and cysteine homeostasis/ferroptosis have recently been identified.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 80Impact of renal cell carcinoma molecular subtypes on immunotherapy and targeted therapy outcomes - 29 day(s) ago
Saliby et al. show that a machine learning approach can accurately classify clear cell renal cell carcinoma (RCC) into distinct molecular subtypes using transcriptomic data. When applied to tumors biospecimens from the JAVELIN Renal 101 (JR101) trial, a benefit is observed with immune checkpoint inhibitor (ICI)-based therapy across all molecular subtypes.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2The OncoAlert Newsletter is NOW OUT Click to Register - 8 month(s) ago
The OncoAlert Newsletter is now out for June 23-29, 2023
Source: www.OncoAlert360.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 18Chromophobe renal cell carcinoma - 9 month(s) ago
Chromophobe renal cell carcinoma (ChRCC) is the second most common variant histology RCC. ChRCC is distinct from clear cell RCC (ccRCC) in terms of ge…
Source: www.sciencedirect.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
AbstractRenal cell carcinoma (RCC) of variant histology comprises approximately 20% of kidney cancer diagnoses, yet the optimal therapy for these patients and the factors that impact immunotherapy response remain largely unknown. To better understand the determinants of immunotherapy response in this population, we characterized blood- and tissue-based immune markers for patients with variant…
Categories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 7
AbstractRenal cell carcinoma (RCC) of variant histology comprises approximately 20% of kidney cancer diagnoses, yet the optimal therapy for these patients and the factors that impact immunotherapy response remain largely unknown. To better understand the determinants of immunotherapy response in this population, we characterized blood- and tissue-based immune markers for patients with variant…
Categories: Latest Headlines, Oncologists1Tweet
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Mashup Score: 4THE ONCOALERT NETWORK - 11 month(s) ago
Welcome to OncoAlert
Source: THE ONCOALERT NETWORKCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Please wait whilst we redirect you - 11 month(s) ago
About ScienceDirectRemote accessShopping cartAdvertiseContact and supportTerms and conditionsPrivacy policyWe use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies.Copyright © 2023 Elsevier B.V. or its licensors or contributors. ScienceDirect® is a registered trademark of Elsevier B.V.ScienceDirect® is a registered trademark…
Source: www.sciencedirect.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 15AKCI - 12 month(s) ago
Our vision is to foster the development and commitment of early career kidney cancer investigators through provision of the raw materials and structured mentorship for focused, sustainable and ultimately independent success. …
Source: AKCICategories: Latest Headlines, Oncologists1Tweet
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Mashup Score: 8
Metabolic homeostasis is one of the most exquisitely tuned systems in mammalian physiology. Metabolic homeostasis requires multiple redundant systems to cooperate to maintain blood glucose concentrations in a narrow range, despite a multitude of physiological and pathophysiological pressures. Cancer is one of the canonical pathophysiological settings in which metabolism plays a key role. In this…
Source: bioRxivCategories: Hem/Oncs, Latest HeadlinesTweet
An outstanding and comprehensive overview of chromophobe RCC biology by @MVossMD #IKCSEU24. Please see the recent review for more discussion on the biology of this tumor type in @Cancer_Cell https://t.co/eC99aihfzW @KidneyCancer https://t.co/mPVRSnQiLl