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Mashup Score: 4Peripapillary atrophy area predicts the decrease of macular choroidal thickness in young adults during myopia progression - 1 month(s) ago
Objective This study aimed to investigate the influence of peripapillary atrophy (PPA) area and axial elongation on the longitudinal changes in macular choroidal thickness (ChT) in young individuals with myopia. Methods and analysis In this longitudinal investigation, 431 eyes—342 categorised as non-high myopia (non-HM) and 89 as HM—were examined for 2 years. Participants were examined with swept-source optical coherence tomography. The macular ChT, PPA area and axial length (AL) were measured at baseline and follow-up visits. Multiple regression analysis was performed to identify factors associated with ChT changes. The areas under the receiver operating characteristic curves were analysed to ascertain the predictive capacity of the PPA area and axial elongation for the reduction in macular ChT. Results Initial measurements revealed that the average macular ChT was 240.35±56.15 µm in the non-HM group and 198.43±50.27 µm in the HM group (p<0.001). It was observed that the HM group expe
Source: bmjophth.bmj.comCategories: General Medicine News, OphthalmologyTweet
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Mashup Score: 1
Purpose To explore the current research about the role of optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in dysthyroid optic neuropathy (DON). Methods Studies in the literature that focused on OCT, OCTA and DON were retrieved by searching PubMed, EMBASE, Cochrane databases and Clinical Trial before 20 June 2023. The methodological quality was assessed using the Newcastle-Ottawa scale. The quantitative calculation was performed using Review Manager V.5.3. Results Twelve studies met the eligibility criteria and were included. DON group presented lower macular ganglion cell complex in the overall, superior and inferior hemifields compared with the non-DON group. Furthermore, the ganglion cell layer and inner plexiform layer in DON group was thinner in contrast to the non-DON group. The optic nerve head vessel density was lower in the DON group than that in the non-DON group. A reduction of radial peripapillary capillary vessel density could be seen
Source: bmjophth.bmj.comCategories: General Medicine News, OphthalmologyTweet
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Mashup Score: 0Impact of smoking on choroidal microvasculature dropout in glaucoma: a cross-sectional study - 2 month(s) ago
Objective To investigate the effect of smoking on choroidal microvasculature dropout (MvD) in glaucoma. Design Cross-sectional study. Setting Tertiary glaucoma centre. Participants 223 eyes of 163 patients with primary open-angle glaucoma who had undergone imaging with optical coherence tomography angiography and completed a questionnaire on smoking from the Diagnostic Innovations in Glaucoma Study. Primary outcome measures Linear mixed-effects models were used to determine the effect of each parameter on MvD area and angular circumference. The sensitivity analysis was performed by categorising the glaucoma severity determined by visual field mean deviation (MD). Results MvD was found in 37 (51.4%) eyes with smoking history and in 67 (44.4%) eyes with non-smokers (p=0.389). Larger MvD area and wider angular circumference were found in smokers compared with non-smokers (p=0.068 and p=0.046, respectively). In a multivariable model, smoking intensity was significantly associated with MvD
Source: bmjophth.bmj.comCategories: General Medicine News, OphthalmologyTweet
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Mashup Score: 15Outer retinal corrugations in late-onset retinal degeneration: a diagnostic finding demonstrated with multimodal imaging - 2 month(s) ago
Objective Late-onset retinal degeneration (L-ORD) is a rare autosomal dominant retinal degeneration that presents in the sixth decade and leads to severe visual loss. The objective of this paper is to describe outer retinal corrugations as a diagnostic feature of L-ORD. Methods This retrospective study reviewed consecutive patients diagnosed with L-ORD, confirmed through complete ophthalmic examination, multimodal imaging and genetic tests. Multimodal imaging investigations included spectral domain-optical coherence tomography (SD-OCT) and ultra-wide-field colour and autofluorescence fundus photographs. Results A total of 13 eyes of 9 patients with L-ORD had outer retinal corrugations identified on OCT scans. Conclusion Outer retinal corrugations may be a diagnostic finding for L-ORD. The detection of this sign may aid diagnosis and characterisation of this disease and help in the differential diagnosis with other acquired pathologies. Data are available on reasonable request. Data are
Source: bmjophth.bmj.comCategories: General Medicine News, OphthalmologyTweet
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Mashup Score: 7Collagen type XII is undetectable in keratoconus Bowman’s layer - 2 month(s) ago
Purpose Corneal biomechanical failure is the hallmark of keratoconus (KC); however, the cause of this failure remains elusive. Collagen type XII ( COL12A1 ), which localises to Bowman’s layer (BL), is thought to function in stress-bearing areas, such as BL. Given the putative protective role of COL12A1 in biomechanical stability, this study aims to characterise COL12A1 expression in all corneal layers involved in KC. Methods TaqMan quantitative PCR was performed on 31 corneal epithelium samples of progressive KC and myopic control eyes. Tissue microarrays were constructed using full-thickness corneas from 61 KC cases during keratoplasty and 18 non-KC autopsy eyes and stained with an antibody specific to COL12A1. Additionally, COL12A1 was knocked out in vitro in immortalised HEK293 cells. Results COL12A1 expression was reduced at transcript levels in KC epithelium compared with controls (ratio: 0.58, p<0.03). Immunohistochemical studies demonstrated that COL12A1 protein expression in BL
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet-
What is the role of #collagen type XII (COL12A1) in the pathogenesis of #keratoconus? A new study from Rigi et al., reveals the implication that in keratoconus patients, COL12A1 in Bowman's layer is undetectable. Read here: https://t.co/HY2shKJeWu #ophthalmology #vision #cornea https://t.co/EbYmc2qVZt
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Mashup Score: 1Continuous 24-hour intraocular pressure monitoring in normal Chinese adults using a novel contact lens sensor system - 2 month(s) ago
Aims To investigate the physiological nyctohemeral intraocular pressure (IOP) rhythms of normal Chinese adults using a novel contact lens sensor system (CLS) that can output IOP in millimetres of mercury (mm Hg) continuously. Methods Fifty-nine eyes of 59 normal Chinese adults completed 24-hour IOP monitoring using the novel CLS. A descriptive analysis was conducted on the 24-hour IOP mean, peak and acrophase, trough and bathyphase, fluctuation, and mean amplitude of intraocular pressure excursion (MAPE). The continuous data were analysed at several periods (diurnal period, 08:00–20:00 hours; nocturnal period, 22:00–06:00 hours; sleep time, 0:00–06:00 hours), and compared between right and left eyes, males and females, and different age ranges (<30, and ≥30), respectively. Results Normal adults had a lower peak, higher trough, smaller fluctuation and smaller MAPE (p<0.05 for all comparisons) but non-significantly different mean (p=0.695) in the nocturnal period or sleep time compared w
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet
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Mashup Score: 1European Glaucoma Society research priorities for glaucoma care - 2 month(s) ago
Background/Aims The goal of health research is to improve patients care and outcomes. Thus, it is essential that research addresses questions that are important to patients and clinicians. The aim of this study was to develop a list of priorities for glaucoma research involving stakeholders from different countries in Europe. Methods We used a three-phase method, including a two-round electronic Delphi survey and a workshop. The clinician and patient electronic surveys were conducted in parallel and independently. For phase I, the survey was distributed to patients from 27 European countries in 6 different languages, and to European Glaucoma Society members, ophthalmologists with expertise in glaucoma care, asking to name up to five research priorities. During phase II, participants were asked to rank the questions identified in phase I using a Likert scale. Phase III was a 1 day workshop with patients and clinicians. The purpose was to make decisions about the 10 most important resear
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet-
Happy Monday! When it comes to treating #glaucoma, what are the relevant priorities from #researchers, #patients, #clinicians, and stakeholders? This study identified 10 research priorities for treating glaucoma here: https://t.co/WA1DzYRqj1. What are your thoughts? #Vision #Eye https://t.co/wpCJ0GNG6i
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Mashup Score: 0Topic Collection | BMJ Open Ophthalmology - 2 month(s) ago
Dyslipidaemia is associated with many retinal metabolic diseases during development and aging. However, the role of lipids in retinal health is not well known. BMJ Open Ophthalmology is calling for submissions on retinal lipid biology including lipid alterations and dyslipidaemia-associated metabolic changes (glucose, amino acid) in retinal diseases, targeting metabolism for disease prevention and treatment. Submissions Open | Submission Deadline: 9th April 2024 We are pleased to offer a 25% discount on
Source: bmjophth.bmj.comCategories: General Medicine News, OphthalmologyTweet
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Mashup Score: 0
Aims Conjunctival melanoma (CoM) is a rare but highly lethal ocular melanoma and there is limited understanding of its genetic background. To update the genetic landscape of CoM, whole-exome sequencing (WES) and targeted next-generation sequencing (NGS) were performed. Methods Among 30 patients who were diagnosed and treated at Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, from January 2018 to January 2023, WES was performed on 16 patients, while targeted NGS was conducted on 14 patients. Samples were analysed to identify the mutated genes, and the potential predictive factors for progression-free survival were evaluated. Furthermore, the expression of the mutated gene was detected and validated in a 30-patient cohort by immunofluorescence. Results Mutations were verified in classic genes, such as BRAF (n=9), NRAS (n=5) and NF1 (n=6). Mutated FAT4 and BRAF were associated with an increased risk for the progression of CoM. Moreover, decreased expres
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet-
A new study in China examined whole genome sequencing in conjunctival #melanoma patients and found high correlations with mutations in BRAF and FAT4 genes. Could these genes be possible therapeutic targets? Read more here https://t.co/4TvdHJLelG #ophthalmology #oncology #cancer https://t.co/2jcnOkfP8g
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Mashup Score: 3Reproducibility of consecutive automated telemetric noctodiurnal IOP profiles as determined by an intraocular implant - 2 month(s) ago
Background Intraocular pressure (IOP) monitoring in glaucoma management is evolving with novel devices. We investigated the reproducibility of 24 hour profiles on two consecutive days and after 30 days of self-measurements via telemetric IOP monitoring. Methods Seven primary patients with open-angle glaucoma previously implanted with a telemetric IOP sensor in one eye underwent automatic measurements throughout 24 hours on two consecutive days (‘day 1’ and ‘day 2’). Patients wore an antenna adjacent to the study eye connected to a reader device to record IOP every 5 min. Also, self-measurements in six of seven patients were collected for a period of 30 days. Analysis included calculation of hourly averages to correlate time-pairs of day 1 versus day 2 and the self-measurements vers day 2. Results The number of IOP measurements per patient ranged between 151 and 268 on day 1, 175 and 268 on day 2 and 19 and 1236 during 30 days of self-measurements. IOP time-pairs of automatic measuremen
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet
In adolescents, eyes with high myopia exhibit a more significant decrease in #macular choroidal thickness than those without high myopia. Peripapillary atrophy area may be used to predict potential #myopia progression in adults: https://t.co/294Ca5Fq5M #retina #vision #eyes https://t.co/MHxhhgYsMW