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Mashup Score: 0
Aims To compare the refractive and visual outcomes of femtosecond laser-assisted astigmatic keratotomy (FSAK) and toric intraocular lens (IOL) implantation for correcting astigmatism in cataract patients. Methods Studies were retrieved from the Ovid-Medline, EMBASE, Cochrane Central Register of Controlled Trials and Scopus which compared FSAK and toric IOL for astigmatism correction in cataract patients. Outcome measures included postoperative refractive cylinder, correction index, uncorrected distance visual acuity (UDVA), the proportion of patients achieving a residual refractive cylinder of 1.00 dioptre or less, target-induced astigmatism (TIA) and surgically induced astigmatism (SIA). The trial sequential analysis (TSA) was used to collect firm evidence supporting our conclusion. Results 9 studies encompassing 590 participants were analysed. The meta-analysis revealed that toric IOLs could result in less postoperative refractive cylinder and provide better UDVA compared with FSAK.
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet
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Mashup Score: 2ICGA-GPT: report generation and question answering for indocyanine green angiography images - 4 day(s) ago
Background Indocyanine green angiography (ICGA) is vital for diagnosing chorioretinal diseases, but its interpretation and patient communication require extensive expertise and time-consuming efforts. We aim to develop a bilingual ICGA report generation and question-answering (QA) system. Methods Our dataset comprised 213 129 ICGA images from 2919 participants. The system comprised two stages: image–text alignment for report generation by a multimodal transformer architecture, and large language model (LLM)-based QA with ICGA text reports and human-input questions. Performance was assessed using both qualitative metrics (including Bilingual Evaluation Understudy (BLEU), Consensus-based Image Description Evaluation (CIDEr), Recall-Oriented Understudy for Gisting Evaluation-Longest Common Subsequence (ROUGE-L), Semantic Propositional Image Caption Evaluation (SPICE), accuracy, sensitivity, specificity, precision and F1 score) and subjective evaluation by three experienced ophthalmologist
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet
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Mashup Score: 1
Aims To assess the safety of femtosecond laser-assisted cataract surgery (FLACS) based on surgical parameters and intraoperative complications analysis and to determine the length of the learning curve for FLACS. Methods A prospective consecutive cohort study was conducted on Chinese patients who underwent either FLACS (3289 cases) or contemporaneous conventional phacoemulsification cataract surgery (2130 cases). The laser group was divided into four subgroups in chronological order. We recorded intraoperative complication incidences and compared with surgical parameters between groups. Subgroup analysis was conducted to explore the learning curve of FLACS. Results The laser group had a 4.93% incidence of incomplete capsulotomies and a 1.22% incidence of anterior capsule tears. Subgroup analysis showed significant differences in 8 aspects between the first 250 cases (50 cases per surgeon) and the last 2539 cases, but only 2 aspects differed between the second 250 cases (50 cases per su
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet-
The learning curve of #femto laser-assisted #cataract surgery is associated with a significant reduction intraoperative complications. New study suggests that the basic learning curve is 100 cases and 150 cases for advanced: https://t.co/cKoMr7kVIu #ophthalmology #vision #health https://t.co/ahHNvuqAo7
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Mashup Score: 1Structural and functional changes of binocular corneal innervation and ocular surface function after unilateral SMILE and tPRK - 10 day(s) ago
Aims To evaluate the bilateral changes in the sub-basal nerve plexus of the cornea and ocular surface function after unilateral small incision lenticule extraction (SMILE) and transepithelial photorefractive keratectomy (tPRK) procedures. Methods 34 patients were enrolled in the study and underwent unilateral SMILE (21 of 34 patients) or unilateral tPRK (13 of 34 patients). Complete ophthalmic examinations, tear film function tests and Cochet-Bonnet esthesiometry were conducted to assess the effects of the surgeries on the corneal nerves and tear function. Morphological changes were assessed using in vivo confocal microscopy to evaluate the corneal sub-basal nerve plexus and dendritic cells. ELISA was used to measure the tear neuromediators. Clinical and morphological data at each follow-up point were compared with preoperative baseline values. Results All patients who underwent unilateral SMILE or tPRK procedures exhibited bilateral corneal nerve degenerative changes, decreased cornea
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet
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Mashup Score: 0A practical approach to uveitis screening in children with juvenile idiopathic arthritis - 15 day(s) ago
Background Juvenile idiopathic arthritis (JIA)-associated uveitis typically presents as a silent chronic anterior uveitis and can lead to blindness. Adherence to current screening guidelines is hampered by complex protocols which rely on the knowledge of specific JIA characteristics. The Multinational Interdisciplinary Working Group for Uveitis in Childhood identified the need to simplify screening to enable local eye care professionals (ECPs), who carry the main burden, to screen children with JIA appropriately and with confidence. Methods A consensus meeting took place in January 2023 in Barcelona, Spain, with an expert panel of 10 paediatric rheumatologists and 5 ophthalmologists with expertise in paediatric uveitis. A summary of the current evidence for JIA screening was presented. A nominal group technique was used to reach consensus. Results The need for a practical but safe approach that allows early uveitis detection was identified by the panel. Three screening recommendations
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet-
The Multinational Interdisciplinary Working Group for Uveitis in Childhood experts developed a simplified and practical #uveitis screening guide for patients with juvenile idiopathic arthritis (JIA) associated uveitis, read here: https://t.co/SnXzVHadsu #rheum #eyes #pediatrics https://t.co/D9LFfPBe6s
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Mashup Score: 0Using artificial intelligence to improve human performance: efficient retinal disease detection training with synthetic images - 1 month(s) ago
Background Artificial intelligence (AI) in medical imaging diagnostics has huge potential, but human judgement is still indispensable. We propose an AI-aided teaching method that leverages generative AI to train students on many images while preserving patient privacy. Methods A web-based course was designed using 600 synthetic ultra-widefield (UWF) retinal images to teach students to detect disease in these images. The images were generated by stable diffusion, a large generative foundation model, which we fine-tuned with 6285 real UWF images from six categories: five retinal diseases (age-related macular degeneration, glaucoma, diabetic retinopathy, retinal detachment and retinal vein occlusion) and normal. 161 trainee orthoptists took the course. They were evaluated with two tests: one consisting of UWF images and another of standard field (SF) images, which the students had not encountered in the course. Both tests contained 120 real patient images, 20 per category. The students to
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet-
NEWS. A team from the Dpt. of Technology and Design Thinking for Medicine in Hiroshima, Japan, has developed a novel artificial intelligence-based teaching aid that leverages generative AI to train ophthalmology students while maintaining patient privacy. https://t.co/kZsRjywI7r https://t.co/TOHQyayaj0
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Mashup Score: 7Collagen type XII is undetectable in keratoconus Bowman’s layer - 2 month(s) ago
Purpose Corneal biomechanical failure is the hallmark of keratoconus (KC); however, the cause of this failure remains elusive. Collagen type XII ( COL12A1 ), which localises to Bowman’s layer (BL), is thought to function in stress-bearing areas, such as BL. Given the putative protective role of COL12A1 in biomechanical stability, this study aims to characterise COL12A1 expression in all corneal layers involved in KC. Methods TaqMan quantitative PCR was performed on 31 corneal epithelium samples of progressive KC and myopic control eyes. Tissue microarrays were constructed using full-thickness corneas from 61 KC cases during keratoplasty and 18 non-KC autopsy eyes and stained with an antibody specific to COL12A1. Additionally, COL12A1 was knocked out in vitro in immortalised HEK293 cells. Results COL12A1 expression was reduced at transcript levels in KC epithelium compared with controls (ratio: 0.58, p<0.03). Immunohistochemical studies demonstrated that COL12A1 protein expression in BL
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet-
What is the role of #collagen type XII (COL12A1) in the pathogenesis of #keratoconus? A new study from Rigi et al., reveals the implication that in keratoconus patients, COL12A1 in Bowman's layer is undetectable. Read here: https://t.co/HY2shKJeWu #ophthalmology #vision #cornea https://t.co/EbYmc2qVZt
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Mashup Score: 1Continuous 24-hour intraocular pressure monitoring in normal Chinese adults using a novel contact lens sensor system - 2 month(s) ago
Aims To investigate the physiological nyctohemeral intraocular pressure (IOP) rhythms of normal Chinese adults using a novel contact lens sensor system (CLS) that can output IOP in millimetres of mercury (mm Hg) continuously. Methods Fifty-nine eyes of 59 normal Chinese adults completed 24-hour IOP monitoring using the novel CLS. A descriptive analysis was conducted on the 24-hour IOP mean, peak and acrophase, trough and bathyphase, fluctuation, and mean amplitude of intraocular pressure excursion (MAPE). The continuous data were analysed at several periods (diurnal period, 08:00–20:00 hours; nocturnal period, 22:00–06:00 hours; sleep time, 0:00–06:00 hours), and compared between right and left eyes, males and females, and different age ranges (<30, and ≥30), respectively. Results Normal adults had a lower peak, higher trough, smaller fluctuation and smaller MAPE (p<0.05 for all comparisons) but non-significantly different mean (p=0.695) in the nocturnal period or sleep time compared w
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet
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Mashup Score: 1European Glaucoma Society research priorities for glaucoma care - 2 month(s) ago
Background/Aims The goal of health research is to improve patients care and outcomes. Thus, it is essential that research addresses questions that are important to patients and clinicians. The aim of this study was to develop a list of priorities for glaucoma research involving stakeholders from different countries in Europe. Methods We used a three-phase method, including a two-round electronic Delphi survey and a workshop. The clinician and patient electronic surveys were conducted in parallel and independently. For phase I, the survey was distributed to patients from 27 European countries in 6 different languages, and to European Glaucoma Society members, ophthalmologists with expertise in glaucoma care, asking to name up to five research priorities. During phase II, participants were asked to rank the questions identified in phase I using a Likert scale. Phase III was a 1 day workshop with patients and clinicians. The purpose was to make decisions about the 10 most important resear
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet-
Happy Monday! When it comes to treating #glaucoma, what are the relevant priorities from #researchers, #patients, #clinicians, and stakeholders? This study identified 10 research priorities for treating glaucoma here: https://t.co/WA1DzYRqj1. What are your thoughts? #Vision #Eye https://t.co/wpCJ0GNG6i
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Mashup Score: 0
Aims Conjunctival melanoma (CoM) is a rare but highly lethal ocular melanoma and there is limited understanding of its genetic background. To update the genetic landscape of CoM, whole-exome sequencing (WES) and targeted next-generation sequencing (NGS) were performed. Methods Among 30 patients who were diagnosed and treated at Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, from January 2018 to January 2023, WES was performed on 16 patients, while targeted NGS was conducted on 14 patients. Samples were analysed to identify the mutated genes, and the potential predictive factors for progression-free survival were evaluated. Furthermore, the expression of the mutated gene was detected and validated in a 30-patient cohort by immunofluorescence. Results Mutations were verified in classic genes, such as BRAF (n=9), NRAS (n=5) and NF1 (n=6). Mutated FAT4 and BRAF were associated with an increased risk for the progression of CoM. Moreover, decreased expres
Source: bjo.bmj.comCategories: General Medicine News, OphthalmologyTweet-
A new study in China examined whole genome sequencing in conjunctival #melanoma patients and found high correlations with mutations in BRAF and FAT4 genes. Could these genes be possible therapeutic targets? Read more here https://t.co/4TvdHJLelG #ophthalmology #oncology #cancer https://t.co/2jcnOkfP8g
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Latest study in #Taiwan reveals that in #cataract patients, toric IOLs result in less postop refractive cylinder and provide better uncorrected distance visual acuity compared with #femto laser-assisted astigmatic keratotomy (FSAK): https://t.co/uZXrjZ6dCa #vision #ophthalmology https://t.co/rYvDm5uF0F