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Mashup Score: 6Hyperacute rejection-engineered oncolytic virus for interventional clinical trial in refractory cancer patients - 5 hour(s) ago
A Newcastle disease virus engineered to enhance anti-tumor immune responses provided a 90% rate of disease control in a clinical trial of 20 patients with diverse refractory cancer types and with distant metastases.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 7
Don’t forget the power of a strong doctor-patient relationship
Source: www.medpagetoday.comCategories: General Medicine News, Hem/OncsTweet-
Thrilled to have my essay on the serendipitous history of Botox and how it relates to the doctor-patient relationship published by @medpagetoday! https://t.co/PN3pKgiSN4
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Mashup Score: 4Uremic Pruritus; Its Prevalence, Pathophysiology and Management - 22 day(s) ago
Open access peer-reviewed chapter
Source: www.intechopen.comCategories: General Medicine News, Hem/OncsTweet-
14/ Some also have theorized that UP is an inflammatory condition, driven by T lymphocyte activation and cytokine production. IL-2 offers an intriguing possible mechanistic explanation, as it can cause itchiness when injected into the skin. https://t.co/5GZpqfUJSO
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Mashup Score: 3Immune deficiency in uremia: interleukin-2 production and responsiveness and interleukin-2 receptor expression and release - PubMed - 22 day(s) ago
We have studied the role of interleukin-2 (IL-2) and its receptors in the impaired in vitro lymphocyte response characteristic of hemodialysis patients treated by means of cuprophane membranes. The proliferative response of T lymphocytes as well as T-cell-dependent B cell proliferation after stimula …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
15/ IL-2 might also explain a surprising association, where patients starting on HD experience new onset or worsening UP. One theory to explain this is that reaction to the HD membranes elicits IL-2 release and worsening pruritis. https://t.co/KJ9zA5hBtW https://t.co/jL96I6qQRV
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Mashup Score: 3Targeting the Opioid Pathway for Uremic Pruritus: A Systematic Review and Meta-analysis - 22 day(s) ago
Patients undergoing hemodialysis or peritoneal dialysis often experience pruritus which is associated with morbidity and mortality. One proposed treatment approach is to target the opioid pathway using either µ-opioid antagonists or κ-opioid …
Source: pmc.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
13/ Yet another purported systemic mechanism involves possible over-expression of endogenous µ-opiate receptors in ESRD. This association is supported by the observation that anti-opiate therapy can be effective in treating UP. https://t.co/BuPLo1Wgp4 https://t.co/zQXI0Xo3gQ
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Mashup Score: 3
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Source: pmc.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
11/ Increases in other serum divalent cations such as Mg might also play a role. Going back to 1979, this patient's UP resolved within a week of decreasing dialysate Mg concentration. This may reflect Mg's ability to impact nerve function. https://t.co/0kwYCw6ZWk https://t.co/yR3y1jbTXx
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Mashup Score: 3Increased plasma histamine levels in uraemic pruritus - PubMed - 22 day(s) ago
1. We determined plasma levels of histamine in uraemic patients and examined their correlation with the presence of pruritus. 2. In 27 patients with chronic renal failure, plasma histamine levels were analysed by radioimmunoassay and were compared with those of 40 healthy adult subjects. The control …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
12/ Histamine almost certainly plays a role as well as it is known to mediate pruritis, and ESRD patients have elevated plasma histamine levels. This results from both increased production and decreased clearance. https://t.co/ztQxGINON4 https://t.co/Jat2pwytEC
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Mashup Score: 4Pruritus in hemodialysis patients - 22 day(s) ago
Pruritus is one of the most bothersome symptoms in patients on maintenance hemodialysis (HD), however little progress is seen in our understanding of its pathogenesis. The aim of this study was to evaluate the frequency of pruritus in HD patients in …
Source: pmc.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
10/ Related to hyperparathyroidism, elevated Ca may contribute to pruritis as well, possibly by subclinical precipitation within the skin. https://t.co/7xS2FBhtli
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Mashup Score: 3
Intractable pruritus as a manifestation of secondary hyperparathyroidism in uremia. Disappearance of itching after subtotal parathyroidectomy
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
9/ The mechanistic association w/ PTH (or metabolic sequela of secondary/tertiary hyperparathyroidism) was supported by a 1968 case series showing resolution of UP in hypercalcemic ESRD patients after partial parathyroidectomy. https://t.co/PuSa1kw08p https://t.co/BM3k7A5f2s
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Mashup Score: 5
The problem of pruritus in uremic dialysed patients remains unsolved. The etiology of pruritus has not been precisely explained, and sometimes no efficient treatment is available. The aim of this study was to analyse the relationship between somatic neuropathy and pruritus as well as the relationshi …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
7/ Another purported cutaneous mechanism is peripheral neuropathy. In a 2001 ESRD cohort study, most of those who had UP also had peripheral nerve dysfunction. https://t.co/4clE1czX0T https://t.co/cKCOMXI2rH
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Crazy cool study investigating alpha-gal gene therapy for refractory solid cancers (leading the immune system to ‘reject’ the cancer like an organ transplant) https://t.co/moVNMUluAL https://t.co/LmU6h0Shcd