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Mashup Score: 13
Cancer mortali ty rates have been steadily declining in the United States for several decades; however, certain types of cancer remain stubbornly lethal, with the lowest five-year survival rates. Effective screening tests are not available for many of these cancers, resulting in the late detection and diagnosis of advanced-stage malignancies for which there is a lack of available therapies with curative potential. The ability to detect and diagnose aggressive precursor lesions or early-stage cancers will
Source: themarkfoundation.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 17Cancer statistics, 2025 - 5 day(s) ago
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes u…
Categories: General Medicine News, Hem/OncsTweet-
Major challenges: - Cancer disparities remain widespread - Cancer incidence in women continues to rise surpassing men in Gen X already - Challenges of recalcitrant cancers like #PancreaticCancer persist Link to the #OpenAccess paper https://t.co/UtlS5vt3bT
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Mashup Score: 12
Abstract. Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through ‘viral mimicry’ responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contributions of repetitive element transcription towards cancer initiation, and the mechanisms by which cancer cells evade lethal viral mimicry responses during tumor initiation remain poorly understood. In this report, we characterize premalignant lesions of the fallopian tube along with syngeneic epithelial ovarian cancer models to explore the earliest events of tumorigenesis following loss of the p53 tumor suppressor protein. We report that p53 loss permits transcription of immunogenic repetitive elements and chronic viral mimicry activation that increases cellular tolerance of cytosolic nucleic acids and diminishes cellular immunogenicity. This selection process can be partially attenuated pharmacologically. Altogether, these results reveal t
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet-
RT @decarvalho_lab: Our recent work on Viral mimicry escape in Ovarian Cancer is out at Cancer Discovery @CD_AACR. https://t.co/DweBjaU4y8
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Mashup Score: 16Cancer statistics, 2025 - 5 day(s) ago
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes u…
Categories: General Medicine News, Hem/OncsTweet-
Major challenges: - Cancer disparities remain widespread - Cancer incidence in women continues to rise surpassing men in Gen X already - Challenges of recalcitrant cancers like #PancreaticCancer persist Link to the #OpenAccess paper https://t.co/UtlS5vt3bT
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Mashup Score: 16Cancer statistics, 2025 - 6 day(s) ago
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes u…
Categories: General Medicine News, Hem/OncsTweet-
Major challenges: - Cancer disparities remain widespread - Cancer incidence in women continues to rise surpassing men in Gen X already - Challenges of recalcitrant cancers like #PancreaticCancer persist Link to the #OpenAccess paper https://t.co/UtlS5vt3bT
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Mashup Score: 3
Abstract. Since the early 1990s, there has been a dramatic rise in gastrointestinal cancers diagnosed in patients under age 50 for reasons that remain poor
Source: academic.oup.comCategories: General Medicine News, Hem/OncsTweet-
Link to paper below: Rethinking the Rise of Early Onset Gastrointestinal Cancers: A Call to Action https://t.co/2APPLKyH9D
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Mashup Score: 16Cancer statistics, 2025 - 6 day(s) ago
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes u…
Categories: General Medicine News, Hem/OncsTweet-
Major challenges: - Cancer disparities remain widespread - Cancer incidence in women continues to rise surpassing men in Gen X already - Challenges of recalcitrant cancers like #PancreaticCancer persist Link to the #OpenAccess paper https://t.co/UtlS5vt3bT
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Mashup Score: 5CD137 agonism enhances anti-PD1 induced activation of expanded CD8+ T cell clones in a neoadjuvant pancreatic cancer clinical trial - 6 day(s) ago
Health sciences; Medicine; Medical specialty; Internal medicine; Oncology
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet-
Link to the paper: https://t.co/zavhY0RqYn
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Mashup Score: 9
Prof. Bai and colleagues discovered that extracellular vesicles derived from pancreatic cancer cells reprogram the tumor microenvironment and augment chemotherapy resistance by transferring the KRASG12D protein to cancer-associated fibroblasts. This finding offers a novel therapeutic strategy for the treatment of pancreatic cancer.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet-
Link to the paper: https://t.co/V7QwMgntTz
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Mashup Score: 2Cancer Prevalence across Vertebrates - 7 day(s) ago
Analysis of 16,049 animal necropsies from 292 vertebrate species shows that cancer prevalence increases with body mass and somatic mutation rates, but decreases with gestation time.
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet-
Link to paper: https://t.co/gJBnkbkAb6
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Letters of intent are now open for @TheMarkFdn @lustgartenfdn @AACR RFA on “Solving the Early Detection and Early-Stage Diagnosis of Recalcitrant Cancers” https://t.co/CB0zIrLT8W Eligible cancers include: •Pancreatic cancer •Hepatobiliary cancers (hepatocellular carcinoma,… https://t.co/IkXmunAXOn