Cancer mortali ty rates have been steadily declining in the United States for several decades; however, certain types of cancer remain stubbornly lethal, with the lowest five-year survival rates. Effective screening tests are not available for many of these cancers, resulting in the late detection and diagnosis of advanced-stage malignancies for which there is a lack of available therapies with curative potential. The ability to detect and diagnose aggressive precursor lesions or early-stage cancers will