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Mashup Score: 2G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics - 8 day(s) ago
Platelets are highly reactive fragments of megakaryocytes that play a fundamental role in thrombosis and hemostasis. Predictably, all conventional anti-platelet therapies elicit bleeding, raising the question whether the thrombotic activity of platelets can be targeted separately. In this study, we describe a novel approach of inhibiting platelet activation through the use of bispecific single-chain variable fragments (bi-scFvs), termed cis-acting platelet receptor inhibitors (CAPRIs) that harness the immunoreceptor tyrosine-based inhibition motif (ITIM)-containing co-inhibitory receptor G6b-B (G6B) to suppress immunoreceptor tyrosine-based (ITAM)-containing receptor-mediated platelet activation. CAPRI-mediated hetero-clustering of G6B with either the ITAM-containing GPVI-FcR γ-chain complex or FcγRIIA (CD32A) inhibited collagen- or immune complex-induced platelet aggregation. G6B-GPVI CAPRIs strongly and specifically inhibited thrombus formation on collagen under arterial shear, where
Source: www.biorxiv.orgCategories: General Medicine News, Cardiologists1Tweet
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Mashup Score: 10An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis - 9 day(s) ago
With advanced age, platelets generated by a differentiation pathway that shortcuts the canonical progenitor cascade to directly make megakaryotic precursor cells from hematopoietic stem cells cause thrombocytosis and are more prone to thrombosis compared with canonically derived platelets.
Source: www.cell.comCategories: General Medicine News, Cardiologists1Tweet
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Mashup Score: 7An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure - 12 day(s) ago
OLFR558/OR51E1 plays an evolutionarily conserved role to mediate sex differences in blood pressure.
Source: www.science.orgCategories: General Medicine News, Cardiologists1Tweet
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Mashup Score: 5
Background Aortic dilatation and pregnancy are major concerns in women with aortopathy (AOP). This single-centre retrospective analysis focuses on the evolution…
Source: journals.sagepub.comCategories: General Medicine News, Cardiologists1Tweet
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Mashup Score: 30
Nature – Under stressful conditions, mesenchymal stromal cells transfer mitochondria to endothelial cells through tunnelling nanotubes, and artificially transplanting mitochondria into endothelial…
Source: www.nature.comCategories: General Medicine News, Cardiologists1Tweet
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Mashup Score: 3Aortic aneurysms in a general population cohort: prevalence and risk factors in men and women - 27 day(s) ago
This study explores two critical hypotheses: i) that the prevalence of thoracic and abdominal aortic aneurysms differs between men and women in a general p
Source: academic.oup.comCategories: General Medicine News, Cardiologists1Tweet
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Mashup Score: 4Ultrasoft platelet-like particles stop bleeding in rodent and porcine models of trauma - 27 day(s) ago
Highly deformable platelet-like particles mitigate bleeding, improve healing responses, and exhibit renal clearance in small and large animal models.
Source: www.science.orgCategories: General Medicine News, Cardiologists1Tweet
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Mashup Score: 2Assessment of Risk for Sudden Cardiac Death Among... - 1 month(s) ago
This report describes a review of Oregon death certificate data to assess whether young people in Oregon might be dying after receiving a COVID-19 vaccine.
Source: www.cdc.govCategories: General Medicine News, Cardiologists1Tweet
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Mashup Score: 2Availability of medical and endovascular therapies for venous thromboembolism: a global survey for World Thrombosis Day - 1 month(s) ago
Data on availability, affordability, and accessibility is key for the planning of global strategies to reduce the burden of venous thromboembolism (VTE).
Source: www.jthjournal.orgCategories: General Medicine News, Cardiologists1Tweet
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Mashup Score: 2Reducing Abdominal Aortic Aneurysm Progression by Blocking Neutrophil Extracellular Traps Depends on Thrombus Formation: - 2 month(s) ago
Highlights •For AAA, surgical repair remains the only treatment to date, with a lack of drug options for management of aneurysm progression or rupture risk.•NETs are implicated in the pathogenesis …
Source: www.jacc.orgCategories: General Medicine News, Cardiologists1Tweet
G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics | bioRxiv https://t.co/Y4q0TKmtbQ