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Mashup Score: 17Immunity by AS03ation: The natural adjuvantage - 1 day(s) ago
Humans do not respond equally to vaccination. To investigate why, Mulè et al. developed a multimodal framework and found that high responders after unadjuvanted influenza vaccination exist in a naturally adjuvanted state, mimicking innate immunophenotypes following AS03-adjuvanted vaccination. This highlights biological factors that set apart high-antibody responders and how adjuvants can boost innate immune cues to improve humoral immunity.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 46
Microglia are brain-resident macrophages that play key roles in brain development and experience dependent plasticity. In this review we discuss recent findings regarding the molecular mechanisms through which mammalian microglia sense the unique molecular patterns of the homeostatic brain. We propose that microglial function is acutely controlled in response to ‘brain-associated molecular patterns’ (BAMPs) that function as indicators of neuronal activity and neural circuit remodeling. A further layer of regulation comes from instructive cytokine cues that define unique microglial functional states. A systematic investigation of the receptors and signaling pathways that mediate these two regulatory axes may begin to define a functional code for microglia–neuron interactions.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 23Non-canonical IKKs side with N4BP1 against the family - 1 day(s) ago
The ubiquitin-binding endoribonuclease N4BP1 is a critical immunosuppressor, but the mechanism by which it acts to constrain TLR-induced inflammatory cytokine production has remained unclear. In this issue of Immunity, Gitlin et al. find that N4BP1 works in concert with the non-canonical IκB kinase (IKK) to limit activity of the IKK complex.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 5
The chronic nature of the hives affecting patients with chronic spontaneous urticaria (CSU) can really affect all aspects of their lives, including sleep, daily activities, work, and interpersonal relationships.
Source: www.ajmc.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 9Slideshow: The 5 Types of Asthma and Their Common Triggers - 1 day(s) ago
While many people may be unaware of the different types of asthma, there are 5 ways individuals can experience the condition, with common triggers that heighten symptoms.
Source: www.drugtopics.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 5Research expands understanding of vaccine-induced immune thrombocytopenia and thrombosis - 1 day(s) ago
New research led by Flinders University and international experts is expanding understanding of vaccine-induced immune thrombocytopenia and thrombosis (known as VITT).
Source: www.news-medical.netCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 5
The more time spent on social media, the greater the likelihood that children and young people will both smoke and/or vape, suggests research published online in the respiratory journal Thorax.
Source: www.news-medical.netCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 67
Stem cells heal wounds. In this issue of Immunity, Luan et al. demonstrate that epidermal stem cells orchestrate the recruitment of regulatory T (Treg) cells and neutrophils during wound healing. Treg cells facilitate a tolerogenic environment to protect epithelial regeneration while neutrophils promote inflammation to ward off infection.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 3Hootsuite - 1 day(s) ago
Enhance your social media management with Hootsuite, the leading social media dashboard. Manage multiple networks and profiles and measure your campaign results.
Source: www.hootsuite.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 5
A significant link between the use of electronic cigarettes and earlier age of asthma onset in U.S. adults was reported by UTHealth Houston researchers May 17, 2024 in JAMA Network Open.
Source: medicalxpress.comCategories: General Medicine News, Allergy-ImmunologyTweet
Immunity by AS03ation: The natural adjuvantage https://t.co/ynPpiFyZFl