Top 10 Stories of 2019 | PNAS
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Wireless arm-worn bioimpedance sensor for continuous assessment of whole-body hydration | PNAS
Assessment of whole-body hydration (WBH) is crucial for health management and disease diagnosis. Traditional methods are invasive or require bulky …
Thalamic CGRP neurons define a spinothalamic pathway for affective pain | PNAS
Pain is both a sensory and emotional experience caused by various harmful stimuli. While numerous studies have explored peripheral and central pain…
Thalamic CGRP neurons define a spinothalamic pathway for affective pain | PNAS
Pain is both a sensory and emotional experience caused by various harmful stimuli. While numerous studies have explored peripheral and central pain…
Akt isoform specificity drives intrinsic immune regulation during HSV-1 infection | PNAS
Akt isoforms are generally considered functionally redundant, contributing to total Akt activity. However, during HSV-1 infection, Akt1 and Akt2 kn…
Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy | PNAS
Lung cancers and melanomas have many somatically mutated self-proteins that would be expected to trigger an immune rejection response, yet therapeu…
Catastrophic climate risks should be neither understated nor overstated | PNAS
Catastrophic climate risks should be neither understated nor overstated
SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses | PNAS
SARS-CoV-2 encodes numerous virulence factors, yet their precise mechanisms of action remain unknown. We provide evidence that the SARS-CoV-2 nonst…
Observing many researchers using the same data and hypothesis reveals a hidden universe of uncertainty | PNAS
This study explores how researchers’ analytical choices affect the reliability of scientific findings. Most discussions of reliability problems in …
Representation of locomotive action affordances in human behavior, brains, and deep neural networks | PNAS
To decide how to move around the world, we must determine which locomotive actions (e.g., walking, swimming, or climbing) are afforded by the immed…
Take caution in using LLMs as human surrogates | PNAS
Recent studies suggest large language models (LLMs) can generate human-like responses, aligning with human behavior in economic experiments, survey…