The utility of macadamia nut legumin Mac i 2 and its conformational epitopes in the diagnosis of macadamia nut allergy
Tree nut (TN) allergies are some of the most common food allergies worldwide. They constitute a major public health challenge and require accurate diagnostic testing. Component-resolved diagnostics have markedly improved TN allergy diagnosis.1 For instance, the 2S albumins of TNs have an important role in diagnosing TN allergy, because many studies reported the superiority of TN 2S albumins compared with extracts.2,3 The diagnostic potential of almond legumin (11S globulin) or macadamia nut vicilin (7S globulin) has recently been recognized, suggesting that levels of IgE specific to TN seed storage proteins other than 2S albumins may also serve as diagnostic markers.