The Journal of Immunology
Read Volume 212 Issue 3 of The Journal of Immunology.
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Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics
Generalized pustular psoriasis (GPP) is a rare human autoinflammatory disorder with life-threatening systemic effects. Keratinocyte-derived interleukin (IL)-36 signaling has been identified as a key mediator…
Targeting molecular pathways to control immune checkpoint inhibitor toxicities
Immune checkpoint inhibitors (ICIs) have transformed cancer treatment but are frequently associated with immune-related adverse events (irAEs). This article offers a novel synthesis of findings…
Brain macrophages in vascular health and dysfunction
Diverse macrophage populations inhabit the rodent and human central nervous system (CNS), including microglia in the parenchyma and border-associated macrophages (BAMs) in the meninges, choroid…
English version of clinical practice guidelines for the management of atopic dermatitis 2024
This is the English version of the 2024 clinical practice guidelines for the management of atopic dermatitis (AD). AD is a disease characterized by relapsing…
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Transcriptional Dynamics of CL Lesions during Treatment See article p. 8942DG and CAR T Cells for Cancer Immunotherapy See article p. 917
Gardners Candies Issues Allergy Alert on Undeclared Tree Nuts in Cappuccino Meltaway® Bars and Gardners Meltaway Treat Boxes Containing Cappuccino Meltaway Bars
Gardners Candies of Tyrone, PA is recalling its 1.25 ounce packages of Gardners Candies brand Cappuccino Meltaway® Bars because they may contain undeclared tree nuts…
Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs
How marginal zone B cells integrate cell-extrinsic and -intrinsic processes to achieve accelerated responsiveness is unclear. Allman et al. combined genetic and pharmacological approaches to establish…
Managing Indoor Allergen Culprits
The AAAAI offers articles written and reviewed by experts on allergies like this one on Managing Indoor Allergen Culprits.
NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1–PD-L1
PD-L1–expressing NK cells restrain cytotoxic CD8+ T cells in the SMG, providing insights into disrupted immunoregulation contributing to irAEs.
Cross-species analyses of thymic mimetic cells reveal evolutionarily ancient origins and both conserved and species-specific elements
Thymic mimetic cells are chimeras between medullary-thymic-epithelial cells (mTECs) and peripheral cell types. Huisman, Michelson, et al. perform high-resolution profiling of human mimetics, revealing a diversification…