An in-depth analysis of IFNs in COVID-19 reveals differences in their roles based on anatomical location, viral load, age, and disease severity. In the upper respiratory tract, high levels of IFN-III are protective and result in mild disease in spite of higher SARS-CoV-2 viral burden, while the lower airways of patients with severe COVID-19 demonstrate elevated IFN-I and IFN-III, cell death, and…
Through SLC6A6-mediated taurine uptake, cancer cells become more aggressive and induce CD8+ T cell exhaustion by increasing ER stress and ATF4 transcription, resulting in immune evasion…
The 55LCC heterohexameric ATPase complex promotes replisome proteostasis to maintain replication fork progression and genome stability.
Using the reconstituted presynaptic terminal local vesicle transport as a paradigm, Qiu and Wu et al. demonstrate that short-distance and directional vesicle transport can be achieved…
The flexible scaffold-based cheminformatics approach (FSCA) unlocks the potential of drug design to create polypharmacological drugs that open up treatment possibilities for complex brain disorders.
A 3D model of an intact Carnegie stage 8 human embryo is constructed from spatial transcriptomics profiling of serial transverse sections.
IGSF8, aberrantly expressed on malignant cells, functions as an innate immune checkpoint that inhibits cytotoxicity of natural killer cells. A monoclonal antibody targeting IGSF8 alone,…
The molecular mechanisms regulating stem cell niche formation are poorly understood. Here, an epitranscriptomic program relying on Mettl3 is uncovered that is distinctly important for…
Naturally inspired protein engineering produces synpoptosis circuits that programmably control user-selectable death programs in target mammalian cells.
(Cell 186, 147–161.e1–15; January 5, 2023)
Zong et al. identified the tumor-derived L-lactate as a natural suppressor of p53 and screened out AARS1 as an intracellular L-lactate sensor and lactyl-transferase that mediates…
