The increasing use of T-cell stimulation for successful dengue vaccination
Dengue fever is a viral infection caused by the dengue virus, which contributes to tens of thousands of deaths annually. Endemic to tropical and subtropical regions, dengue virus is transmitted by Aedes mosquitoes that breed in warm stagnant waters. Upon biting a susceptible host, the virus is transferred to the bloodstream, leading, in most people, to fever and vomiting. At its worst, dengue virus can lead to internal bleeding and death. As an arbovirus (ie, an arthropod-borne virus), the number of dengue-virus infections in an area are often closely linked to mosquito breeding habits, leading to a cyclical pattern of widespread transmission spanning 3–4 years.