Ma et al. identify P4HA1 as a critical regulator of CD8+ T cell activity in solid tumor microenvironment. P4HA1 induction in CD8+ T cells causes mitochondrial dysfunction and immune exhaustion. P4HA1 inhibition enhances the progenitor CD8+ T cell expansion while mitigating exhaustion, leading to enhanced systemic anti-tumor immunity.
MCL-1, an anti-apoptotic protein required for intestinal homeostasis, has been associated with chemoresistance in colorectal cancer. This study provides novel insights into the molecular profile…
The Year in Review in Oncology 2024 brought to you by some of the Worlds TOP experts!
Tagitanlimab received marketing authorization from the Chinese NMPA for use with cisplatin and gemcitabine for patients with recurrent or metastatic NPC.
An additional 1-year of follow-up confirmed the safety and activity of SHR-A1811 in HER2-expressing or -mutant solid tumors, including breast cancer.
Gabriel Mannis, MD, discusses the observed clinical activity and manageable safety profile of IO-202 combined with azacitidine in CMML.
Nguyen et al. demonstrate that loss of acetyl-CoA synthesis enzymes in mouse skin depletes key epidermal barrier lipids, disrupts the skin barrier, and causes rapid fat…
Maurie Markman, MD, delves into questions regarding precision medicine and genetic testing in cancer.
In this Blood Spotlight, Huls et al highlight why small molecule inhibitors of menin are creating excitement in the acute myeloid leukemia (AML) field with
The NIH said capping indirect cost payments will save billions of dollars. Universities said it will disrupt vital, life-saving research.
Alexander Watson, MD, DPhil, FRCPC, details findings showing oncogene overlap is adequately applied to NGS-based tissue sampling by decreasing frequency and increasing copy number gain.
