Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma
Hoang et al. shows that DNA methyltransferase 3A (DNMT3A) regulates cellular energy production in mitochondria and contributes to the resistance of mantle cell lymphoma to ibrutinib, an inhibitor of Bruton tyrosine kinase. Targeting DNMT3A with low-dose decitabine is a potential therapeutic strategy to overcome ibrutinib resistance.