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Mashup Score: 8
Genetically engineered porcine hearts may have an application for infants in need of a bridge to cardiac allotransplantation. The current animal model that resulted in 2 human applications has been validated in adult non-human primates only. We sought to create an infant animal model of life sustaining cardiac xenotransplantation to understand limitations specific to this age group.
Source: www.jhltonline.orgCategories: General Medicine NewsTweet
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Mashup Score: 1
According to the Health Resources and Services Administration, more than 100,000 people in the United States are currently on the waiting list to receive an organ transplant, and an average of 17 people die every day on the waiting list. Join our host, Dr. Sam Kant, and guest, Dr. Robert Montgomery, as they discuss a practice that has the potential to mitigate this issue and take kidney transplantation into the next frontier- Xenotransplantation.
Categories: General Medicine News, NephrologyTweet-
🚨 Medical Milestone Alert! 🚨 Want to learn more about #Xenotransplantation? Check out our interview with Dr. Montgomery, the surgeon behind this life-changing operation, to hear about the science, challenges, and incredible potential. 🔗https://t.co/SlKtTlbbiv https://t.co/ex9Gct90G6
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Mashup Score: 5Extended survival of 9- and 10-gene-edited pig heart xenografts with ischemia minimization and CD154 costimulation blockade-based immunosuppression - 5 month(s) ago
Xenotransplantation has made significant advances recently using pigs genetically engineered to remove carbohydrate antigens, either alone or with addition of various human complement, coagulation, and anti-inflammatory ‘‘transgenes’’. Here we evaluated results associated with gene-edited (GE) pig hearts transplanted in baboons using an established costimulation-based immunosuppressive regimen and a cold-perfused graft preservation technique.
Source: www.jhltonline.orgCategories: General Medicine News, CardiologistsTweet-
Multiple gene-edited pig hearts were transplanted into 8 baboons utilizing ischemia minimization techniques. This study demonstrated prolonged survival in a preclinical baboon model using CD154 blockade with TNX-1500. #Xenotransplantation 🔗: https://t.co/QJpWQYArvG https://t.co/u55jMs7yPh
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Mashup Score: 9
The first transplant surgery to combine a mechanical heart pump as well as a gene-edited pig kidney has been completed at NYU Langone Health, the system said Wednesday.
Source: www.cnn.comCategories: General Medicine News, General HCPsTweet-
The first transplant surgery to combine a mechanical heart pump as well as a gene-edited pig kidney has been completed at @nyulangone #xenotransplantation https://t.co/F6kpCkbUKy
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Mashup Score: 13Progress in xenotransplantation: overcoming immune barriers - Nature Reviews Nephrology - 1 year(s) ago
This Review summarizes the current state of knowledge regarding immunological barriers to xenotransplantation and discusses the major approaches that are being used to overcome these barriers, including immunosuppression, genetic engineering of pigs and tolerance induction.
Source: www.nature.comCategories: General Medicine News, NephrologyTweet-
Tolerance and immune function with transplantation of swine (or hybrid) thymus and mixed xenogeneic chimerism. #xenotransplantation https://t.co/sX73Aywzft https://t.co/4gWNiSSt82
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Mashup Score: 64Progress in xenotransplantation: overcoming immune barriers - Nature Reviews Nephrology - 1 year(s) ago
This Review summarizes the current state of knowledge regarding immunological barriers to xenotransplantation and discusses the major approaches that are being used to overcome these barriers, including immunosuppression, genetic engineering of pigs and tolerance induction.
Source: www.nature.comCategories: General Medicine News, NephrologyTweet-
Progress in #xenotransplantation. A Review from Megan Sykes & David Sachs @CCTI_NYC https://t.co/71HA6RXRpu https://t.co/8HCAdUV0wI
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Mashup Score: 0UM Medicine Faculty-Scientists and Clinicians Perform Second Historic Transplant of Pig Heart into Patient with End-Stage Cardiovascular Disease - 2 year(s) ago
September 25, 2023 —  After world’s first successful transplant in 2022, also performed at the University of Maryland Medical Center (UMMC), this groundbreaking transplant team performed second pig heart transplant on patient deemed ineligible for traditional heart transplant. A 58-year-old patient with terminal heart disease became the second patient in the world to receive a historic transplant of a genetically-modified pig heart on September 20. He is recovering and communicating with his loved ones. This is only the second time in the world that a genetically modified pig heart has been transplanted into a living patient.  Both historic surgeries were performed by University of Maryland School of Medicine (UMSOM) faculty at the University of Maryland Medical Center (UMMC). The first historic surgery, performed in January, 2022, was conducted on David Bennett by University of Maryland Medicine surgeons (comprising UMSOM and UMMC), who are recognized as the leaders in cardiac xenot
Source: www.dicardiology.comCategories: Cardiologists, Latest HeadlinesTweet-
@DAICeditor @UMmedschool Landmark #cardiac #xenotransplantation procedure conducted at University of Maryland Medical Center: https://t.co/cXPNjKy2Cp #pigheart @artificialheart #transplant
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Mashup Score: 3NYU surgeons say transplant of pig kidney to human marks advance - 2 year(s) ago
A genetically altered pig kidney has functioned for 32 days in a man declared neurologically dead. His heart is still beating and he is breathing with the aid of a respirator.
Source: www.washingtonpost.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
A genetically altered pig kidney transplanted into a brain dead patient has continued to function for 32 days, an advance toward the possible use #xenotransplantation in humans. https://t.co/rtS10GtqUf
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Mashup Score: 1
Wednesday, 19Â April, 2023 FEATURED ABSTRACTS After an exciting conference welcome from program chairs Andreas Zuckermann, MD and Howard Eisen, MD, this featured abstract was introduced wherein Sebastien Hascoet, MD, PhD and colleagues from Marie Lannelongue Hospital in Paris, France presented a retrospective cohort study comparing 61 consecutive pediatric patients with severe pulmonary artery…
Source: www.ishlt.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Saturday in HEART #ISHLT2023: @JasonGoldbergMD, @LuiseHolzhauser, and #PeiJunZhao covered #PedsTx outcomes, multi-organ transplantation, and novel research in mitochondria and #xenotransplantation. https://t.co/j1iOa8ebKt https://t.co/0ZwfLCS7FO
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Mashup Score: 0Milestones on the path to clinical pig organ xenotransplantation - 2 year(s) ago
Progress in pig organ xenotransplantation has been made largely through (1) genetic engineering of the organ-source pig to protect its tissues from th…
Source: www.sciencedirect.comCategories: Latest Headlines, SurgeryTweet-
Milestones on the path to clinical pig organ #xenotransplantation https://t.co/2wpNVI8042 https://t.co/rumJI212Dl
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Animal model of #xenotransplantation (genetically modified pig to baboon) imparts lessons on longevity, cardiac performance, and immunosuppression 🔗: https://t.co/PVfqx5Nzd5 https://t.co/ssVtVQymte