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Mashup Score: 0Chemotherapy-Induced Tunneling Nanotubes Mediate Intercellular Drug Efflux in Pancreatic Cancer - Scientific Reports - 1 year(s) ago
Intercellular communication plays a critical role in the ever-evolving landscape of invasive cancers. Recent studies have elucidated the potential role of tunneling nanotubes (TNTs) in this function. TNTs are long, filamentous, actin-based cell protrusions that mediate direct cell-to-cell communication between malignant cells. In this study, we investigated the formation of TNTs in response to…
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0The role of tunneling nanotubes during early stages of HIV infection and reactivation: implications in HIV cure - 1 year(s) ago
Tunneling nanotubes (TNTs), also called cytonemes or tumor microtubes, correspond to cellular processes that enable long-range communication. TNTs are plasma membrane extensions that form tubular processes that connect the cytoplasm of two or more cells. TNTs are mostly expressed during the early stages of development and poorly expressed in adulthood. However, in disease conditions such as…
Source: De GruyterCategories: Hem/Oncs, Latest HeadlinesTweet-
"The role of tunneling nanotubes during early stages of HIV infection and reactivation: implications in HIV cure" - from lab of Dr. Eliseo Eugenin @utmbhealth @utmbnews https://t.co/QDjV7jmCGf @degruyter_pub #tunnelingnanotubes #cellbiology #HIV #infectiousdiseases https://t.co/3r9Ei7sF7z
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Mashup Score: 2
Contents“A happy accident”A microtubule is not the same as a membrane nanotubuleCommunication is everything, also for the cellThe message of a cellNanotubules May Help Cancer…
Source: SamaGameCategories: Hem/Oncs, Latest HeadlinesTweet-
Interesting piece on the history of discovery of #tunnelingnanotubes and how the field is coming together to understand their role in cancer. 'this is how they move, organize and communicate at the cellular level'--https://t.co/NYNKSjcCVc #cellbiology #SNO2022 #CellBio2022
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Mashup Score: 0Ovarian Cancer Midwest Focus - 1 year(s) ago
Maria Barbolina, PhD, from the University of Illinois Cancer Center, presenting on Microtubules (MTs) and their Dynamics in Chemo-Resistant Ovarian Cancer. Ron Buckanovich, MD, PhD, from the Magee-Womens Research Institute, presenting on Ovarian Cancer Models: A Humanized Model of Ovarian Cancer. Uri Ben-David, PhD, from the Tel Aviv University, presenting on Aneuploidy in Cancer and in…
Categories: Hem/Oncs, Latest HeadlinesTweet-
A major theme of the 2022 Ovarian Cancer Midwest Focus Conference is the important role of intercellular communication occurring via #tunnelingnanotubes and #exosomes/#extracellularvesicles #EVs (and it's not just coming from me, I promise!) #OCRF #gyncsm https://t.co/dnWN0t1HSc
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Mashup Score: 0
Background Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication. Valid assays are needed to accurately assess the downstream effects of TNT-mediated transfer of cellular signals in vitro. We recently reported a modified transwell assay system…
Source: SpringerLinkCategories: Hem/Oncs, Latest HeadlinesTweet-
Auto-email via @SpringerNature for the win, reminding me of this assay we published 5 years ago at the intersection of #TunnelingNanotubes and #Exosomes/#ExtracellularVesicles. They are not mutually exclusive when it comes to cell-cell communication! https://t.co/QFE7r9FCug https://t.co/s0uFjEegDC
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Mashup Score: 0TNTdetect.AI: A Deep Learning Model for Automated Detection and Counting of Tunneling Nanotubes in Microscopy Images - 2 year(s) ago
Background: Tunneling nanotubes (TNTs) are cellular structures connecting cell membranes and mediating intercellular communication. TNTs are manually identified and counted by a trained investigator; however, this process is time-intensive. We therefore sought to develop an automated approach for quantitative analysis of TNTs. Methods: We used a convolutional neural network (U-Net) deep learning…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet-
Working link here: https://t.co/X0dTpLjg9w New publication to creating an algorithm for automating identification: https://t.co/47NhUAOBnj: A Deep Learning Model for Automated Detection and Counting of #TunnelingNanotubes in Microscopy Images - #microscopy #cellbiology https://t.co/nZSfJBlgj0
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Mashup Score: 2Cancer Cell Nanotubes Hijack Mitochondria from Immune Sentinels - 2 year(s) ago
The mitochondria stolen via these tiny connections give tumor cells a metabolic boost while the T cells are left weakened, according to in vitro experiments.
Source: The Scientist Magazine®Categories: Hem/Oncs, Latest HeadlinesTweet-
Cancer Cell Nanotubes Hijack Mitochondria from Immune Sentinels https://t.co/FSHIBkEoJF #TunnelingNanotubes #CellBiology #cancerresearch #immunology #immunotherapy https://t.co/AIdBGHK5i5
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Mashup Score: 0Mesenchymal Stromal Cell Mitochondrial Transfer as a Cell Rescue Strategy in Regenerative Medicine: A Review of Evidence in Preclinical Models - 2 year(s) ago
Abstract. Mesenchymal stromal cells (MSC) have excellent clinical potential and numerous properties that ease its clinical translation. Mitochondria play a cruc
Source: OUP AcademicCategories: Hem/Oncs, Latest HeadlinesTweet-
Next stop: Clinical relevance? https://t.co/Ob4r6i9ZcF Mesenchymal Stromal Cell Mitochondrial Transfer as a Cell Rescue Strategy in Regenerative Medicine: A Review of Evidence in Preclinical Models @StemCellsTM @StemCellsJournl @IsevOrg https://t.co/xc8qpkTR3E https://t.co/KCzeZSlWQ1
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Review article in @StemCellsTM on 'Mesenchymal Stromal Cell Mitochondrial Transfer as a Cell Rescue Strategy in Regenerative Medicine' delves into mechanisms of that transfer, including #TunnelingNanotubes, Cell Fusion, EVs, Gap Junctions, and more. https://t.co/Ob4r6i9ZcF https://t.co/h5yjNZidqY
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Mashup Score: 1
Tunneling nanotubes (TNTs) comprise a unique class of actin-rich nanoscale membranous protrusions. They enable long-distance intercellular communication and may play an integral role in tumor formation, progression, and drug resistance. TNTs are three-dimensional, but nearly all studies have investigated them using two-dimensional cell culture models. Here, we applied a unique 3D culture platform…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet-
This is the link to the recently published #openaccess paper from our team that the image is from: Tunneling Nanotubes between Cells Migrating in ECM Mimicking Fibrous Environments https://t.co/7TTMSiE79d #tunnelingnanotubes #cellbiology @MRC_LMS @UMNCancer https://t.co/7tgM7mwo0P
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Mashup Score: 2
Tunneling nanotubes (TNTs) comprise a unique class of actin-rich nanoscale membranous protrusions. They enable long-distance intercellular communication and may play an integral role in tumor formation, progression, and drug resistance. TNTs are three-dimensional, but nearly all studies have investigated them using two-dimensional cell culture models. Here, we applied a unique 3D culture platform…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet-
"The Long and Winding Road" of cancer cell communication: a long and hooked tunneling nanotube mediating transport of cell cargo packages. From: #TunnelingNanotubes between Cells Migrating in ECM Mimicking Fibrous Environments https://t.co/mWtTvIo7u2 @Amrinder_Nain & my team https://t.co/3J0mdLDqMg
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#TunnelingNanotubes create intercellular communication networks that help drive invasive potential and evolution of drug resistance including in #pancreaticcancer & #coloncancer. This includes cell-to-cell transfer of RAS https://t.co/6a58TfJeSs https://t.co/b1AsQq9wjQ #GI23 https://t.co/xVDEVCbHAG https://t.co/iaWz32Wtiy