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Mashup Score: 0
The benefit of pharmacogenetic testing before starting drug therapy has been well documented for several single gene–drug combinations. However, the c…
Source: www.sciencedirect.comCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 0
This interim analysis provides support for considering carfilzomib, lenalidomide, and dexamethasone therapy in patients with newly diagnosed multiple myeloma who completed any induction regimen followed by autologous stem-cell transplantation, which requires confirmation after longer follow-up of this ongoing phase 3 trial.
Source: The Lancet OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
ICYMI: Carfilzomib, lenalidomide, & dexamethasone vs lenalidomide alone as maintenance therapy after #ASCT for #MultipleMyeloma in the phase 3 ATLAS #trial https://t.co/JxusNYkfAd #mmsm
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Mashup Score: 0Exclusion of pregnant and lactating women from COVID-19 vaccine trials: a missed opportunity - 1 year(s) ago
In the midst of a devastating pandemic with high transmissibility and case fatality, the mRNA COVID-19 vaccine trials represent hope of an end to the global bur
Source: OUP AcademicCategories: Cardiologists, Latest HeadlinesTweet-
“The treatment of many conditions during #pregnancy or #lactation relies on historic drugs that have only observational data to confirm safety.”.. “Lack of #trial data puts a burden on patient and physician to decide if the treatment is safe to continue” https://t.co/MSro0Fimyt https://t.co/mEZl5b1sMi https://t.co/db0G9mQleU
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Mashup Score: 0A randomised trial of a T2-composite-biomarker strategy adjusting corticosteroidtreatment in severe asthma, a post- hoc analysis by sex - 1 year(s) ago
Approximately 5–10% of patients with asthma have severe disease with a consistent preponderance in females. Current asthma guidelines recommend stepwise treatment to achieve symptom control with no differential treatment considerations for either sex.
Categories: Allergy-Immunology, Latest HeadlinesTweet-
In Press! A randomised #trial of a T2-composite-#biomarker strategy adjusting #corticosteroid #treatment in severe #asthma, a post- hoc analysis by sex https://t.co/dSD03Nk1eA
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Mashup Score: 3
To our knowledge, this study is the largest randomised anaplastic thyroid cancer study that has completed accrual showing feasibility in a multicenter NCI National Clinical Trials Network setting. Although no significant improvement in overall survival was recorded in the pazopanib group, the treatment combination was shown to be feasible and safe, and hypothesis-generating data that might…
Source: The Lancet OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Online first: #Radiotherapy+paclitaxel+pazopanib or placebo in anaplastic #thyroid #cancer: a randomised phase 2 #trial https://t.co/2F44nx0ekN
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Mashup Score: 0Lopinavir/ritonavir for Treatment of Non-Hospitalized Patients with COVID-19: A Randomized Clinical Trial - 1 year(s) ago
Introduction
Categories: Latest Headlines, PulmonologyTweet-
#Lopinavir/ #ritonavir for #Treatment of Non-Hospitalized #Patients with #COVID-19: A Randomized #Clinical #Trial https://t.co/lXGdnQmD3c https://t.co/H9XRXhbsDw
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Mashup Score: 0Early-Phase Clinical Trials of Bio-Artificial Organ Technology: A Systematic Review of Ethical Issues - 1 year(s) ago
Regenerative medicine has emerged as a novel alternative solution to organ failure which circumvents the issue of organ shortage. In preclinical research settings bio-artificial organs are being developed. It is anticipated that eventually it will be possible to launch first-in-human transplantation trials to test safety and efficacy in human recipients. In early-phase transplantation trials,…
Source: FrontiersCategories: Latest Headlines, TransplantationTweet-
What is the evidence on #ethics for safe design and conduction of early phase #bioartificial #organ clinical #trial? 👉 Read the systematic #review 🔗https://t.co/UDYjDBGW5u part of our special issue: Hot topics in transplant ethics, donation and policies https://t.co/ZCYKuiKZOC https://t.co/pwRpoC5iZI
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Mashup Score: 1(1) Post | LinkedIn - 1 year(s) ago
Univ.-Prof.Dr. Ralph Stephan von Bardeleben Univ.-Professor Interv. Klappentherapie, Head Heart Valve Center, Editor in Chief Echocardiography, Full Professor Interventional Heart Valve Tx Cardiology JGU University of Mainz, ACHD EMAH View full profile
Source: www.linkedin.comCategories: Cardiologists, Latest HeadlinesTweet-
#Triluminate #Trial #Data #RCT and the #NewFrontier of #Tricuspid #heartvalve #repair at #PCRLV in late 2022 see more at https://t.co/UKhF0i6WVN https://t.co/S0Ie8Gayw1
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Mashup Score: 1
Background This trial aimed to analyse the safety, effectiveness and transcriptomic characteristics of neoadjuvant toripalimab plus chemotherapy in II–III non-small-cell lung cancer (NSCLC). Methods Patient eligibility mainly involved treatment-naive, clinical stage II–III and wild-type EGFR/ALK NSCLC. The patients received 2–4 cycles of toripalimab (240 mg q3w) plus carboplatin-based…
Source: BioMed CentralCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Latest article in our Targeted Therapies #cancer collection: phase 2 #trial testing #toripalimab plus chemotherapy in stage II–III #NSCLC finds this combination to be both safe and effective. https://t.co/h6dphmqZpq Full collection here: https://t.co/1rVFQDALnT https://t.co/An8bDhaJRi
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Mashup Score: 0
November 23, 2022 — In 2015, published findings from the landmark Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive blood pressure management reduced cardiovascular disease and lowered the risk of death. In 2019, results of the SPRINT MIND trial showed that lowering blood pressure also reduced the risk of mild cognitive impairment in older adults. Now, researchers from…
Source: DAICCategories: Cardiologists, Latest HeadlinesTweet-
@DAICeditor @wakeforestmed While intensive #bloodpressure control was beneficial to #SPRINT participants during the #trial, the benefits for cardiovascular mortality went away after approximately 2 years when protocols were no longer being followed: https://t.co/ICHNOMxcXL
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Results of this innovative study highlight why #trial #representativeness is important for reliable estimates of #drug #safety. Requiring 🧬 panels to guide 💊care - for nominal gains - will be 👎🏽 for health system #cost, #GDMT access, #healthequity https://t.co/YwK0O4JJ3X