• Mashup Score: 7
    Nature Cancer - Shedding light on PARP inhibitor therapy for PDAC - 2 year(s) ago

    METTL16–RNA complexes sensitize pancreatic adenocarcinoma cells to inhibitors of the DNA-repair enzyme PARP1 by hindering DNA end resection.See Zeng et…

    Source: Nature
    Categories: Hem/Onc News and Journals, Latest Headlines
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      NatureCancer

      The @NatureCancer 🍂SEPTEMBER ISSUE🍃 is out - it is beautiful on the outside🧬and filled with exciting science on #Immunotherapy #Covid19 #TherapyResistance #Artificial_Intelligence #DigitalPathology #CancerPlasticity! DON'T MISS IT 👇 https://t.co/UJzEHQw93u https://t.co/tFgLYNYBby

  • Mashup Score: 3
    Volume 22 Issue 6, June 2022 - 2 year(s) ago

    Editorial Editorial …

    Source: www.nature.com
    Categories: Hem/Onc News and Journals, Latest Headlines
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      NatureRevCancer

      Our June issue, out NOW! With articles on #therapyresistance, #senescence & targeting CDK4 & CDK6 in #cancer! Plus, a Comment on cancer mRNA vaccines as well as the launch of our new Tools of the Trade articles #NRCToT. So much content 👇🏻 💌 https://t.co/Fo6XRWV3OZ @natrescancer https://t.co/rbxRPqLV6g

  • Mashup Score: 7
    Programmed death ligand 1 signals in cancer cells - Nature Reviews Cancer - 2 year(s) ago

    Cancer cell-intrinsic PDL1 signals present novel drug discovery targets and also have potential as treatment response biomarkers. This Perspective discusses our understanding of cancer cell-intrinsic PDL1 signals, mechanisms for signal controls and immunopathological consequences including resistance to cytotoxic agents, targeted small molecules and immunotherapies.

    Source: Nature
    Categories: Hem/Onc News and Journals, Latest Headlines
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      NatureRevCancer

      In the March issue of @NatureRevCancer | #PDL1 signals in #cancer cells by AVR Kornepati, RK Vadlamudi & TJ Curiel https://t.co/KKhYovCQgF @natrescancer #ImmuneCheckpoint #immunotherapies #therapyresistance https://t.co/ksH6wCXpKj

  • Mashup Score: 2
    Overcoming therapy resistance in EGFR-mutant lung cancer - Nature Cancer - 2 year(s) ago

    Passaro and colleagues discuss recent advances in treating EGFR-mutant lung cancer, including methods for detecting disease and tracking therapy response, developments in understanding of resistance mechanisms and ongoing clinical trials to circumvent therapeutic resistance to EGFR targeting.

    Source: Nature
    Categories: Hem/Onc News and Journals, Latest Headlines
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      NatureCancer

      📑“Overcoming #TherapyResistance in EGFR-mutant lung cancer”, a Review by @peters_solange & Co @NatureCancer Find it at: https://t.co/Pr1ipcj5wY #IWD2022 #InternationalWomensDay https://t.co/3XeyotUJnN

  • Mashup Score: 20
    Towards targeting of shared mechanisms of cancer metastasis and therapy resistance - Nature Reviews Cancer - 2 year(s) ago

    This Perspective outlines how the signalling pathways enabling metastasis are often shared with those supporting resistance to cancer therapies. Identifying nodes within these shared signalling networks that could be targeted might result in more effective therapies for the treatment of rapidly growing solid tumours.

    Source: Nature
    Categories: Hem/Onc News and Journals, Latest Headlines
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      NatureRevCancer

      In the March issue of @NatureRevCancer | Towards targeting of shared mechanisms of #cancer #metastasis & #therapyresistance by F Weiss, D Lauffenburger & P Friedl https://t.co/V2dElqiwyC @natrescancer @MDAndersonNews @radboudumc @radboudumc_weet #CancerTherapy https://t.co/HemVmlAHh7

  • Mashup Score: 0
    Volume 22 Issue 3, March 2022 - 2 year(s) ago

    Volume 22 Issue 3, March 2022

    Source: www.nature.com
    Categories: Hem/Onc News and Journals, Latest Headlines
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      NatureRevCancer

      Our March issue, out NOW! With articles on pancreatic #cancer evolution, tobacco #carcinogens, shared mechanisms of #metastasis & #therapyresistance & #PDL1 signals! Plus a Comment on racial disparities in acral #melanoma research. 💌 https://t.co/ao93JUFzOy @natrescancer https://t.co/nS6ZY7eOzo

  • Mashup Score: 56
    Towards targeting of shared mechanisms of cancer metastasis and therapy resistance - Nature Reviews Cancer - 2 year(s) ago

    This Perspective outlines how the signalling pathways enabling metastasis are often shared with those supporting resistance to cancer therapies. Identifying nodes within these shared signalling networks that could be targeted might result in more effective therapies for the treatment of rapidly growing solid tumours.

    Source: Nature
    Categories: Hem/Onc News and Journals, Latest Headlines
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      NatureRevCancer

      NEW Perspective! Friedl et al outline how exploitation of signalling pathways shared between those enabling #Metastasis and those in #TherapyResistance might result in better therapies. https://t.co/V2dElqiwyC @natrescancer @MDAndersonNews @Radboudumc @Radboudumc_weet https://t.co/ZCDAKZnCAC

  • Mashup Score: 4
    The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs - Nature Reviews Cancer - 2 year(s) ago

    BH3-mimetic drugs have been designed to directly induce apoptosis in cancer cells by targeting prosurvival BCL-2 family proteins. This Review discusses their continued development and the challenges arising from their implementation in the clinic, such as resistance or on-target toxic effects, and the approaches that could be harnessed to overcome these obstacles.

    Source: Nature
    Categories: Hem/Onc News and Journals, Latest Headlines
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      In the Jan issue of @NatureRevCancer | The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs, by Andreas Strasser, Gemma L. Kelly et al. ⚡https://t.co/x9Op9qO1u4 @natrescancer @WEHI_research #CancerTherapy #TherapyResistance https://t.co/zSrcgemJDH

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