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Mashup Score: 44MHC heterozygosity limits T cell receptor variability in CD4 T cells - 3 month(s) ago
TCR repertoires in MHC heterozygote mice have unexpected holes and are smaller than the sum of those of their related homozygotes.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 13Re-“Formate” T-cell Antitumor Responses - 9 month(s) ago
Summary:. Rowe and colleagues discover that one-carbon (1C) metabolism rewiring occurs upon T-cell activation to support proliferation and cytolytic activity in CD8+ T cells and that supplementation of 1C donor formate rescues the dysfunctional T cells and their responsiveness to anti–PD-1 in selective tumor-infiltrated T-cell subsets. This finding represents an attractive strategy to overcome a metabolic vulnerability in the tumor microenvironment and improve the efficacy of immune checkpoint blockade.See related article by Rowe et al., p. 2566 (8).
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 6Re-“Formate” T-cell Antitumor Responses - 10 month(s) ago
Summary:. Rowe and colleagues discover that one-carbon (1C) metabolism rewiring occurs upon T-cell activation to support proliferation and cytolytic activity in CD8+ T cells and that supplementation of 1C donor formate rescues the dysfunctional T cells and their responsiveness to anti–PD-1 in selective tumor-infiltrated T-cell subsets. This finding represents an attractive strategy to overcome a metabolic vulnerability in the tumor microenvironment and improve the efficacy of immune checkpoint blockade.See related article by Rowe et al., p. 2566 (8).
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 4Personalized T cell immunotherapy for pediatric brain tumors is one step closer to becoming a reality - 3 year(s) ago
Children’s National Hospital experts developed a new approach that discovered unique proteins in an individual tumor’s cells, which then helped scientists generate personalized T cells to target and kill tumors, according to a pre-clinical study published in Nature Communications.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet
A new @SciImmunology study in mice offers a better look at how #Tcell receptor repertoire is selected, with possible implications for vaccine #immunotherapy development. Learn more: https://t.co/cxaNTMsBUX https://t.co/CagfKmvpW8